L11-diabetes

Question 1

what is diabetes

Answer 1

hligh glucose

Question 2

causes of diabtees

Answer 2

insufficent action of insulin

Question 3

classification of diabetes

Answer 3

Type 1,2 - causes by mutiple genes

monogenic - a rare condition resulting from mutations (changes) in a single gene.

Question 4

feature of type 1 deficicency

Answer 4

absolute insulin deificiency

Question 5

causes of type 1 diabetes

Answer 5

insulitis, autoimmune od beta cells

Question 6

features of tyoe 2 diabetes

Answer 6

insulin reistance

• relative insulin deficiency
• genetic disposition
• insulin not required to sustain life

Question 7

causes of type 2

Answer 7

INSULIN REsistance

pancreatic beta cells dysfunction

Question 8

diagnosis od diabtes

Answer 8

measure urine glucose

>6.5%

Question 9

things that cause insulin reisistance and B cell dysfunction

Answer 9

diabetes genes
adipokines 
inflamm
hypergly
Free FAs
other factors

Question 10

function of somatostatin

Answer 10

regulates hormones screted from a and B cekls

Question 11

aplha cells can be inhibited by

Answer 11

somatostatin and GABA

Question 12

what is TCF7L2-1

Answer 12

transcrption factor 7like 2

Question 13

function of TCF7L2-1

Answer 13

regulates LDL, VLDL, HDL
- regulates insulin scretion
regulates adipogenesis

Question 14

treatment for type 1

Answer 14

lifestyle

insulin injections

Question 15

treatment for typ2

Answer 15

lifesytlde
reduce insulin R 
increase insulin secretion, 
insulin ijnections 
incretins

Question 16

function fo metformin

Answer 16

icreases insulin sensitivity and increase uptake of glucose

Question 17

actions of metformin

Answer 17

block gluconeogenesis

-increase glucose uptake

Question 18

function of sulphonylureas

Answer 18

stimulates insulin release from beta eclls

Question 19

complication of diabetes

Answer 19

stroke
eyes
heart disease
peripheral vascular disease
nerve 
kidneys