L: 28/29 Zaidi review

Question 1

Where does fatty acid synthesis occur?

Answer 1

Primarily Liver

Also in adipose, brain, kidney, lactating mammary glands

Question 2

What is the end product of FA synthesis

Answer 2

Palmitic Acid (16 C molecule)

Question 3

Precursor to FA synthesis

Answer 3

Acetyl-CoA (2 C molecule)

Question 4

Phase 1 of synthesis of FA

Answer 4

Cytosolic entry of Acetyl CoA

Question 5

Phase2 of FA synthesis

Answer 5

Generation of Malonyl CoA

Question 6

Phase 3 of FA synthesis

Answer 6

Fatty acid chain formation

Question 7

What is the rate limiting enzyme of FA biosynthesis pathway?

Answer 7

Acetyl CoA Carboxylase (ACC)

Question 8

What regulates the conversion of Citrate converted back to Acetyl CoA and OAA during cytosolic entry?

Answer 8

Positive- Glucose and Insulin

Negative- PUFA, leptin

Question 9

What is the rate limiting step in FA biosynthesis?

Answer 9

ACC

adds a Co2 to acetyl CoA using ATP and Biotin as co-factor

Question 10

What inhibits carnitine acyltransferase and is the rate limiting step for FA degradation

Answer 10

Malonyl CoA

Question 11

Where does the reaction of fatty acid synthesis occur on?

Answer 11

Fatty Acid Synthase (FAS)

Complex