L 25 Drug Abuse Flashcards
What is Cross Tolerance?
person becomes tolerant to a drug working at a certain receptor
= tolerance also to other drugs working at same receptor
Types of Cannabinoids?
Endogenous – anandamide, 2- arachidonylglycerol
Plant – THC
Synthetic – JWH
Cannabinoids MOA?
cannabinoid agonists
CB1, CB2
Cannabinoids OD symptoms?
cardio effects
psychoses
What are CNS stimulants?
amphetamines
methamphetamines
methylphenidate
cocaine
ephedrine
mephedrone
CNS Stimulants MOA?
indirect acting sympatho.
INC DA & NE
Withdrawal symptoms of CNS stimulants?
mild
depressed state
changes in mood, sleep, appetite
CNS Stimulant dependence Tx?
antidepressants
What are Dissociative Anesthetics?
ketamine
phencyclidine
Dissociative Anesthetics MOA?
NMDA ANTAGONIST
Dissociative Anesthetics withdrawal symptoms? OD?
life threatening – Withdrawal
OD– life support, maintain airway
Dissociative Anesthetics dependence Tx?
benzodiazepines
What are Hallucinogen drugs?
serotonergics
anticholinergics
What is special about Hallucinogens?
do NOT produce dependence, withdrawal
Rapid TOLERANCE develops
What are Serotonergic drugs?
Tryptamines
Phenalkylamines
Phenethylamines
Serotonergics MOA?
SE AGONIST
Sertonergics OD Tx?
2nd gen antipsychotics
What are Anticholinergic drugs?
atropine
scopolamine
Anticholinergic MOA?
muscarinic ANTAGONIST
Anticholinergic OD Tx?
cholinesterase inhibitor
–> Physostigmine
Opiods MOA?
mu opioid AGONIST
What kind of tolerance with Opioids?
Differential tolerance
Tx for Opioid induced constipation?
naloxegol
Opioid withdrawal symptoms?
vasoconstrict
cold sensation
severe cramp
muscle spasm
