L 25 Drug Abuse Flashcards by Mac Mac | Brainscape

Q

What is Cross Tolerance?

A

person becomes tolerant to a drug working at a certain receptor

= tolerance also to other drugs working at same receptor

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Q

Types of Cannabinoids?

A

Endogenous – anandamide, 2- arachidonylglycerol

Plant – THC

Synthetic – JWH

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Q

Cannabinoids MOA?

A

cannabinoid agonists

CB1, CB2

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Q

Cannabinoids OD symptoms?

A

cardio effects

psychoses

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Q

What are CNS stimulants?

A

amphetamines

methamphetamines

methylphenidate

cocaine

ephedrine

mephedrone

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Q

CNS Stimulants MOA?

A

indirect acting sympatho.

INC DA & NE

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Q

Withdrawal symptoms of CNS stimulants?

A

mild

depressed state

changes in mood, sleep, appetite

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Q

CNS Stimulant dependence Tx?

A

antidepressants

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Q

What are Dissociative Anesthetics?

A

ketamine

phencyclidine

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Q

Dissociative Anesthetics MOA?

A

NMDA ANTAGONIST

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Q

Dissociative Anesthetics withdrawal symptoms? OD?

A

life threatening – Withdrawal

OD– life support, maintain airway

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Q

Dissociative Anesthetics dependence Tx?

A

benzodiazepines

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Q

What are Hallucinogen drugs?

A

serotonergics

anticholinergics

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Q

What is special about Hallucinogens?

A

do NOT produce dependence, withdrawal

Rapid TOLERANCE develops

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Q

What are Serotonergic drugs?

A

Tryptamines

Phenalkylamines

Phenethylamines

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Q

Serotonergics MOA?

A

SE AGONIST

Q

Sertonergics OD Tx?

A

2nd gen antipsychotics

Q

What are Anticholinergic drugs?

A

atropine

scopolamine

Q

Anticholinergic MOA?

A

muscarinic ANTAGONIST

Q

Anticholinergic OD Tx?

A

cholinesterase inhibitor

–> Physostigmine

Q

Opiods MOA?

A

mu opioid AGONIST

Q

What kind of tolerance with Opioids?

A

Differential tolerance

Q

Tx for Opioid induced constipation?

A

naloxegol

Q

Opioid withdrawal symptoms?

A

vasoconstrict

cold sensation

severe cramp

muscle spasm

Q

Opioid physical dependence Tx?

A

Substitution Therapy

> Methadone
> Buprenorphine

Antagonist Therapy
-> Naltrexone

Q

Opioid OD Tx?

A

Naloxone

Q

Sedative Hypnotic Drugs?

A

barbiturates

benzodiazepines

alcohol

Q

Sedative Hypnotic MOA?

A

+ allosteric modulators of GABAa

Q

Sedative Hypnotic physical dependence Tx?

A

benzodiazepines

Q

Alcohol abuse therapy?

A

disulfiram

Q

What are Volatile Intoxicants?

A

Anesthetics – ether, NO

Solvents – acetone, glue, paint thinner, gasoline

Q

What is special about Volatile Intoxicants?

A

produces TOLERANCE

no PHYS. DEPENDENCE
-> bc short duration

Q

Volatile Intoxicants withdrawal symptoms?

A

seizures

Q

Nicotine MOA?

A

nicotine AGONIST

Q

Nicotine dependence Tx?

A

bupropion

varenicline