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Pharm Test 3 > L 19 Antipsychotic > Flashcards

L 19 Antipsychotic Flashcards

1
Q

What are the 3 classes of 1st generation Antipsychotics?

A

Phenothiazines

Butyrophenones

Thioxanthenes

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2
Q

What are the 4 classes of the 2nd generation Antipsychotics?

A

Dibenzodiazepines

Benzisoxazoles

Misc. Heterocyclics

Partial DA agonists

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3
Q

Neuroleptic Syndrome includes effects such as?

A

sedation

emotional quieting

psychomotor slowing

affective indifference

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4
Q

Aliphatics MOA?

A

low affinity D2 antagonists

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5
Q

Piperdines MOA?

A

higher affinity for D2 (than aliphatics)

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6
Q

Piperazines MOA?

A

high affinity D2 antagonist

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7
Q

What drugs are the least sedating of the D2 Antagonists?

A

Piperazines

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8
Q

1st Generation Butyrophenones MOA?

A

high to intermediate affinity for D2

Inc risk of extrapyramidal SE

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9
Q

What drugs are Butyrophenones?

A

Droperidol

Haloperidol

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10
Q

Droperidol SE?

A

prolong QT

Torsades

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11
Q

2nd Generation advantages?

A

weakly antidopaminergic

Dec tardives, parkinsonism

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12
Q

Clozapine therapeutic uses?

A

pt with negative antipsychotic symptoms

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13
Q

Clozapine SE?

A

agranulocytosis

myocarditis

cardiomyopathy

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14
Q

What needs to be monitored for a pt taking Clozapine?

A

troponin

cardiomyopathy

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15
Q

Olanzapine SE?

A

sleep walking

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16
Q

Benzisoxazoles MOA?

A

selective serotonin type 2A antagonists

At higher doses have Haloperidol effects

17
Q

Lurasidone MOA?

A

activity at several 5HT receptors involved in learning and memory

lacks anticholinergic effects

18
Q

Paliperidone MOA?

A

primary active metabolite of resperidone

antagonize D2 & SE

19
Q

Asenapine therapeutic use?

A

adults with schizo

manic or mixed episodes Bipolar 1 w/ or w/out psychotic features

20
Q

Pimozide therapeutic use?

A

severe tics

involuntary vocalization w/ Tourettes

21
Q

What drug is a partial agonist?

A

Aripiprazole

22
Q

Aripiprazole Therapeutic uses?

A

reduce:
neurolepsis
parkinsonism
tardive

that occur with the D2 antagonists

23
Q

Aliphatics risk?

A

autonomic SE

24
Q

Piperdines risk?

A

quinidine effects on heart

25
Q

Piperazines risk?

A

extrapyramidal effects

Pharm Test 3 (8 decks)

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