L 18 DRUGS anti coagulants Flashcards by Mac Mac | Brainscape

Q

Aspirin (ASA) MOA?

A

Low dose:
sel. (-) TX A2 synthesis

High dose:
inhibit prostacyclin production and DEC efficacy of ASA

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Q

What is the antiplatelet drug of choice?

A

Aspirin

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Q

Aspirin SE?

A

inc hemorrhagic stroke

GI bleed

tinnitus

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Q

Aspirin contraindications?

A

children with viral illness

-> reyes syndrome

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Q

Clopidogrel MOA?

A

irreversible (-) P2Y12

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Q

Clopidogrel therapeutic uses?

A

Dec:
stroke

MI

unstable angina

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Q

Clopidogrel SE?

A

bleeding

TTP

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Q

Ticlopidine MOA?

A

irreversible (-) P2Y12

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Q

Ticlopidine therapeutic uses?

A

standard practice in combo w/ ASA

prevent stent thrombosis

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Q

Ticlopidine SE?

A

N/V
Diarrhea
Bleed

Neutropenia

TTP

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Q

Abciximab MOA?

A

Fab fragment of antibody targeting GP2b/3a

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Q

Epitifibatide MOA?

A

peptide (-) of fibrinogen binding site of GP2b/3a

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Q

Dipyridamole MOA?

A

(-) thrombus formation
(-) PDE
(-) adenosine uptake

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Q

Dipyridamole therapeutic use?

A

CV ischemia

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Q

Dabigatran Etexilate MOA?

A

direct thrombin (-)

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Q

Dabigatran Etexilate therapeutic use?

A

dec stroke in pt w/ atrial fib
DVT
Pul Embolism

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Q

Dabigatran Etexilate benefits?

A

less pt monitoring

equal to warfarin

rapid onset

less SE

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Q

Dabigatran Etexilate SE?

A

bleed

heartburn

stomach

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Q

Hirudin MOA?

A

irreversible thrombin (-)

Q

Hirudin therapeutic uses?

A

thrombosis

bc heparin induced thrombocytopenia

Q

Argatroban MOA?

A

reversible thrombin (-)

Q

Argatroban therapeutic uses?

A

pt w/ or at risk of heparin induced thrombocytopenia

Q

Bivalirudin MOA?

A

reversible thrombin (-)

Q

Bivalirudin therapeutic use?

A

coronary angioplasty

Q

HMW Heparin MOA?

A

(-) 9a, 10a, thrombin

by INC Antithrombin 3

Q

How to administer HMW heparin?

A

IV or SC

i.m = cause hematomas

Q

HMW Heparin SE?

A

Heparin induced thrombo.

Q

How to Tx OD of HMW Heparin?

A

Protamine Sulfate

Q

LMW Heparin MOA?

A

(-) 10a by ANTITHROMBIN

Q

LMW Heparin therapeutic use?

A

venous thromboembolism

thrombosis

pul. embolism

unstable angina

Q

LMW Heparin Advantages?

A

Longer 1/2 life

1 daily SC injections

Dec thrombocytopenia, osteoporosis

Less pt monitoring

Q

Fondaparinux MOA?

A

(-) 10a by antithrombin only

Q

Fondaparinux therapeutic uses?

A

venous thromboembolism

thrombosis

pul embolism

Q

Fondaparinux advantages?

A

longer 1/2 life

1x daily SC

Dec thrombocytopenia, osteoporosis

Dec pt monitoring

Q

Rivaroxaban MOA?

A

(-) 10a

indirectly (-) maturation of Thrombin

Q

Rovaroxaban advantage over Warfarin?

A

no titration

Q

Rivaroxaban therapeutic uses?

A

venous thromboembolism after knee/ hip replacement

DVT

Dec thrombosis in pt w/ Fib

Q

Warfarin MOA?

A

(-) Vit K epokide reductase

lower Vit K recycling

slow maturation of prothrombin, 7, 9, 10

Q

Warfarin therapeutic uses?

A

Acute DVT

Pul Embolism

Venous thromboembolism

Acute MI

Prosthetic heart valve

Chronic Afib

Q

Warfarin SE?

A

crosses the placenta

developmental defects

hemorrhage

Q

What is used to reverse Warfarin?

A

Phytonadione (Vit K)

Q

What drugs INC Warfarin potency?

A

Aspirin

Vit K def.

Anabolic Steroid

Antibiotics

Tamoxifen

Oral Hypoglycemics

Q

What drugs DEC Warfarin potency?

A

alcohol

oral BC

corticosteroids

barbiturates

Inc Vit K

Cholestyramine

Green Veggies

Q

Streptokinase therapeutic use?

A

I.v. ASAP after heart attack to dissolve clots

Q

tPA MOA?

A

activates plasminogen bound to fibrin

Q

tPA therapeutic use?

A

lysing thrombi for tx MI

Q

What are tPA derivatives?

A

Reteplase – less clot specific

Tenecteplasen– clot specific