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Pharm Test 3 > L 20 Anti Parkinsons > Flashcards

L 20 Anti Parkinsons Flashcards

1
Q

What are the Anticholinergic drugs?

A

Benztropine

Procyclidine

Trihexyphenidyl

Diphenydramine

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2
Q

Trihexyphenidyl MOA?

A

inhibit Ach

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3
Q

Benzotropine MOA?

A

block muscarinic receptors in striatum

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4
Q

Procyclidine MOA?

A

Relieving rigidity & salivation

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5
Q

Adverse effects of anticholinergic drugs?

A

constipation

urinary retention

confusion

hallucinations

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6
Q

Benedryl MOA?

A

anticholinergic

block DA reuptake

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7
Q

Diphenhydramine therapeutic uses?

A

elderly who can’t tolerate

L-dopa

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8
Q

L- Dopa MOA?

A

precursor to DA

rapid onset– large doses needed

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9
Q

Combine L-Dopa with?

A

peripherally acting dopacarboxylase inhibitor that can’t cross BBB to prevent premature metabolism

Carbidopa

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10
Q

L-Dopa problems?

A

Requires DA neurons to make it DA

Effectiveness reduce after 2-5 yrs

On/Off effect

Parkinsons Symptoms

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11
Q

L-Dopa peripheral SE?

A

Nausea/ Vomit

Tachy

Orth. HTN

Arrythmia

Anorexia

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12
Q

L-Dopa central SE?

A

Hallucinations

Delusions

Motor Fluctuations

Dyskinesias

Vivid Dreams

Sleep Disturbance

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13
Q

Dangerous L-Dopa drug combinations?

A

MAO (-) – HTN, Stroke

Adrenomimetic amines – asthma/ emphysema tx – arrhythmia

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14
Q

DA agonists SE?

A

Stimulate DA sites directly

Long duration, less effect. than L-Dopa

Delay initiation of L-Dopa

Somnolence, Insomnia, Fatigue

Receptor desensitize – Inc symptoms

Impulse control disorder

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15
Q

What drugs are D2/D3 Agonists?

A

Pramipexole

Ropinirole

Rotigotine

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16
Q

COMT Inhibitor drugs?

A

Entacapone

Tolcapone

17
Q

Entacapone MOA?

A

inhibits peripheral COMT

18
Q

Tolcapone MOA?

A

inhibits peripheral & central COMT

19
Q

COMT Inhibitors MOA?

A

(-) metabolization of DA & L-Dopa

to inactive 3-O-methyl DOPA

20
Q

COMT inhibitors SE?

A

Athoptosis

Confusion/ Hallucinations

Possible Fatal Hepatotoxicity

21
Q

What needs to be monitored for a pt on Tolcapone?

A

liver enzymes

22
Q

MAO-B Inhibitor Drugs?

A

Selegiline

Rasagiline

23
Q

MAO-B Inhibitor MOA?

A

inhibits DA metabolism

can delay L-dopa

24
Q

Dont combine MAO-B inhibitor with?

A

tricyclic antidepressants

selective serotonin uptake inhibitors

25
Q

Amantadine MOA?

A

antiviral

26
Q

What are adjunct therapies for more advanced PD pt?

A

Antipsychotics & Cog. Enhancers

Clozapine

Donepezil – Cholinesterase (-)

Pharm Test 3 (8 decks)

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