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Pharm Test 3 > 23, 24 CNS Depressants > Flashcards

23, 24 CNS Depressants Flashcards

1
Q

What are the Barbiturate drugs?

A

Na Thiopental
Thiamylal
Methohexital

Secobarbital
Pentobarbital

Phenobarbital

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2
Q

Barbiturates MOA?

A

(+) allosteric GABA A modulator

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3
Q

How are Barbiturates inactivated?

A

redistribution

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4
Q

How are Barbiturates metabolized and excreted?

A

metabolized- liver

excrete- kidney

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5
Q

Barbiturates therapeutic uses?

A

induce anesthesia

tx epilepsy

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6
Q

Barbiturates adverse effects?

A

CNS, Resp. depress

Tolerance

Dependence

Abuse

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7
Q

What are Barbiturates drug interactions?

A

CNS depressant= additive effects

stimulation of liver enzymes, INC rate of destruction of several drugs

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8
Q

What drugs are Benzodiazepines?

A

Midazolam
Triazolam

Alprazolam
Chlordiazepoxide
Lorazepam
Oxazepam
Temazepam

Diazepam
Clonazepam

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9
Q

Midazolam therapeutic uses?

A

conscious sedation & same day surgery

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10
Q

Triazolam therapeutic uses?

A

sedative hypnotic

conscious sed. off label

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11
Q

Alprazolam therapeutic uses?

A

anxiety, depression, panic

don’t use bc of dependence

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12
Q

Chlordiazepoxide therapeutic uses?

A

anxiety

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13
Q

Lorazepam therapeutic uses?

A

1st choice for status epi.

medical restraint cocktail

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14
Q

Oxazepam therapeutic uses?

A

situational short term anxiety

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15
Q

Temazepam therapeutic uses?

A

sedative hypnotic

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16
Q

Diazepam therapeutic use?

A

anxiety

1st choice for status epi

17
Q

Clonazepam therapeutic use?

A

chronic & acute anxiety

18
Q

What is the antagonist for Benzodiazepines?

A

flumazenil

19
Q

What drugs are secreted into breast milk?

A

Benzodiazepines

20
Q

Benzodiazepines Reduction Phase 1 Metabolism:

A

elderly

drugs can inhibit hepatic met.

liver disease

21
Q

Benzodiazepines MOA?

A

(+) GABA A medulators

DONT ACTIVATE GABAA DIRECTLY AT LARGE DOSES

22
Q

Benzodiazepines clinical indications?

A

anxiolytic

sedative

muscle relaxant

anticonvulsant

anesthesia induction

23
Q

Benzodiazepines SE?

A

CNS depression

anterograde amnesia

resp. effects

tolerance

dependence

abuse

thrombophlebitis

24
Q

Benzodiazepines contraindications?

A

pregnancy
lactation

angle glaucoma

25
Q

Benzodiazepines drug interactions?

A

other CNS depressants

anticonvulsants

antipsychotics

opioids

26
Q

What drugs are Non Benzodiazepine sedative hypnotics?

A

zolpidem

zopiclone

eszopiclone

zaleplon

27
Q

What are Anti Depressant Drugs?

A

trazodone

doxepin

28
Q

Meprobamate tx?

A

anxiety

abuse risk

29
Q

Buspirone Tx?

A

GAD

30
Q

Buspirone MOA?

A

SE agonist

31
Q

Cyclobenzaprine Tx?

A

muscle spasm, TMJ

32
Q

Cyclobenzaprine SE?

A

GI

xerostomia

sedation

dizzy

33
Q

Carisoprodol Tx?

A

skeletal muscle relaxant

34
Q

Baclofen Tx?

A

anti spasticity

trigeminal neuralgia

MS

ALS

35
Q

Tizanidine Tx?

A

anti spasticity

alpha 2 agonist

36
Q

Dantrolene Tx?

A

malignant hyperthermia

Pharm Test 3 (8 decks)

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