23, 24 CNS Depressants Flashcards
What are the Barbiturate drugs?
Na Thiopental
Thiamylal
Methohexital
Secobarbital
Pentobarbital
Phenobarbital
Barbiturates MOA?
(+) allosteric GABA A modulator
How are Barbiturates inactivated?
redistribution
How are Barbiturates metabolized and excreted?
metabolized- liver
excrete- kidney
Barbiturates therapeutic uses?
induce anesthesia
tx epilepsy
Barbiturates adverse effects?
CNS, Resp. depress
Tolerance
Dependence
Abuse
What are Barbiturates drug interactions?
CNS depressant= additive effects
stimulation of liver enzymes, INC rate of destruction of several drugs
What drugs are Benzodiazepines?
Midazolam
Triazolam
Alprazolam Chlordiazepoxide Lorazepam Oxazepam Temazepam
Diazepam
Clonazepam
Midazolam therapeutic uses?
conscious sedation & same day surgery
Triazolam therapeutic uses?
sedative hypnotic
conscious sed. off label
Alprazolam therapeutic uses?
anxiety, depression, panic
don’t use bc of dependence
Chlordiazepoxide therapeutic uses?
anxiety
Lorazepam therapeutic uses?
1st choice for status epi.
medical restraint cocktail
Oxazepam therapeutic uses?
situational short term anxiety
Temazepam therapeutic uses?
sedative hypnotic
Diazepam therapeutic use?
anxiety
1st choice for status epi
Clonazepam therapeutic use?
chronic & acute anxiety
What is the antagonist for Benzodiazepines?
flumazenil
What drugs are secreted into breast milk?
Benzodiazepines
Benzodiazepines Reduction Phase 1 Metabolism:
elderly
drugs can inhibit hepatic met.
liver disease
Benzodiazepines MOA?
(+) GABA A medulators
DONT ACTIVATE GABAA DIRECTLY AT LARGE DOSES
Benzodiazepines clinical indications?
anxiolytic
sedative
muscle relaxant
anticonvulsant
anesthesia induction
Benzodiazepines SE?
CNS depression
anterograde amnesia
resp. effects
tolerance
dependence
abuse
thrombophlebitis
Benzodiazepines contraindications?
pregnancy
lactation
angle glaucoma
