L 23

Question 1

What TF controls Treg development? Cytokines?

Answer 1

FoxP3
IL 10
TGF beta

Question 2

What TF controls Th1 development? Cytokines?

Answer 2

T-bet
IL 12
IFN gamma

Question 3

What TF controls Th2 development? Cytokines?

Answer 3

GATA 3

IL 4

Question 4

What TF controls Th17 development? Cytokines?

Answer 4

ROR
IL 6
IL 21

Question 5

What is indirect allograft rejection?

Answer 5

Donor cells died

Digested & presented by recipient APC (MHC2)

Question 6

What is direct allograft rejection?

Answer 6

Donor APCs (MHC2) are recognized by recipient APCs

Question 7

What are the 3 immune responses that lead to graft rejection?

Answer 7

1. DTH - activated macrophages
2. Abs against graft
3. CD8 direct killing graft

Question 8

Is indirect or direct presentation linked to acute cellular rejection?

Answer 8

Direct

Question 9

What type of injury are you concerned about with a transplanted organ? Which type of immunity does this trigger?

Answer 9

Ischemia reperfusion
From a dead donor - guaranteed some level of inflam
Will trigger innate immunity when transplanted

Question 10

What is hyperacute rejection?

Answer 10

Patient who has been immunized to a donor
IMMEDIATE rejection
PREVENTABLE - this should never happen!!!!!!

Question 11

What is chronic rejection?

Answer 11

B cell Abs continuously attack the allograft over time
Cells killed –> fibroblasts –> organ loses fxn over time
This is still an issue b/c we don’t have good drugs to interrupt B cells

Question 12

What are some drugs you can use for immunosuppression post transplant?

Answer 12

mAbs vs IL 2-R

Belatacept

Question 13

Describe features of patients that are high risk for rejection.

Answer 13

Not 1st transplant
Black/hispanic
Dead donor
Poor HLA match