Konorev Anti-arrhythmic drugs part 2 Flashcards
What is a proarrhythmia?
Drug induced significant new arrhythmia or worsening of an existing arrhythmia
What are nonpharmacological treatments of arrhythmias?
- Catheter ablation
- Implantable cardioverter defibrillator
- Artificial cardiac pacemaker
- Direct current cardioversion
What drug classes trigger an excessive slowing of repolarization leading to torsades de pointes?
- Class 1A
- Na channel blockers
- Class 3
- K channel blockers
What class of drugs triggers excessive slowing of conduction leading to persistent ventricular tachycardias?
- Class 1A
- Quinidine
- Procainamide
- Disopyramide
- Class 1C
- Flecainide
- Propafenone
- Both classes are Na channel blockers
What is the most common arrhythmia? How does it present?
- A. fib
- Fatigue, weakness, decreased exercise tolerance
- Hypotension
- Pulmonary congestion
- Exacerbation HF
What is the mechanism behind A. fib?
- Reentry circuits
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what are the two approaches to treat A.fib?
- Rhythm control
- Rate control
Describe rhythm control approach to A. fib?
- Direct current cardioversion
- Chemical cardioversion using Class 1C (Na blocker) or class 3 (K channel blocker)
Which drugs will be effective in interrupting reentry currents in A fib?
- Esmolol & Quinidine
- Mexiletine & Lidocaine
- Verapamil & adenosine
- Sotalol & Flecainide
- Propafenone & diltiazem
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Sotalol & Flecainide
- sotalol is Class 3 K blocker
- Flecainide is 1C
- Esmolol is class 2 Beta blocker
- Quinidine is class 1A Na channel block
- Mexiletine and Lidocaine are class 1B Na channel
- Verapamil & Diltiazem are Ca channel block
- Propafenone class 1C Na channel
How do you maintain sinus rhythm in AF patients with minimal heart disease?
- Catheter ablation
- Flecainide
- 1C
- Propafenone
- 1C
- Sotalol
- class 3
- Amiodarone
- class 3
- Dofetilide
- class 3
In patients with structural disease what class of drugs are contraindicaated?
Class 1C
In order to maintain sinus rhythm in A fib patients with structural disease what is done/used?
- Catheter ablation
- Sotalol
- Class 3
- Amiodarone
- Class 3
- Dofetilide
- Class 3
What is the CHADS VASc tool?
Helps identify if patients need to be on antithrombotic therapy
- Congestive HF
- Htn
- Age >75
- DM
- Stroke
- Vascular dz
- Age 65-74
- Sex
What agents are used for stroke prevention in most patients with AF?
- Dabigatran
- Rivaroxaban
- Edoxaban
- Apixaban
- Warfarin
- Konorev not testing, but Wolff will later on
What is Paroxysmal supraventricular tachycardia? Most common type?
- Abrupt onset and termination of tachycardia
- Most common is AV nodal reentrant tachycardia