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CPR 2 Exam 1 > Konorev Adrenergic Drugs Part 1 > Flashcards

Konorev Adrenergic Drugs Part 1 Flashcards

1
Q

What are the direct acting adrenomimetics Alpha agonists?

A
  • Phenylephrine
  • Clonidine
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2
Q

What are the direct acting adrenomimetics mixed alpha and beta agonists?

A
  • Norepinephrine
  • Epinephrine
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3
Q

What are the direct acting adrenomimetic beta agonists?

A
  • Dobutamine
  • Isoproterenol
  • Albuterol
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4
Q

What are the indirect adrenomimetics that inhibit re uptake of DA and NE?

A
  • Cocaine
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5
Q

What are the indir3ect adrenomimetics that inhibit MAO?

A
  • Selegiline
  • Phenelzine
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6
Q

What are the indirect adrenomimetics that increase NE and DA release?

A
  • Amphetamines
  • Methylphenidate
  • Tyramine
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7
Q

What are the indirect adrenomimetic releasing agen and direct adrenergic receptor agonists?

A

Ephedrine

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8
Q

Adrenergic drugs control function of what specific nervous system?

A
  • Sympathetic
  • they mimic or promote effects of NE/E/DA
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9
Q

What do the alpha 1 receptors do intracellularly?

A
  • Increase IP3, DAG
  • they are Gq
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10
Q

What do alpha 2 receptors cause intracellularly to happen? What GPCR type?

A
  • Decrease in cAMP
  • Gi
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11
Q

What do Beta type receptors cause intracellularly? GPCR type?

A
  • increase cAMP
  • Gs
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12
Q

What do dopamine type 1 receptors do?

A

Increase cAMP they are a Gs

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13
Q

What do dopamine type 2 receptors do?

A

Decrease cAMP, they are Gi

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14
Q

Activation of which adrenergic receptor will decreaSe pkA activity in target tissues?

A

alpha 2

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15
Q

Phenylephrine targets what receptor the most?

A

Alpha 1 > Alpha2 >>>>> Beta

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16
Q

Clonidine targets what receptor?

A

alpha 2 > alpha 1 >>>> Beta

Alpha agonists direct adrenomimetics

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17
Q

NE receptor targets?

A

alpha 1 = alpha 2

B1>>B2

Direct adrenomimetic

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18
Q

What receptors does Epinephrine target?

A

alpha1=alpha2

Beta1=Beta2

Direct adrenomimetic

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19
Q

What does Dobutamine target?

A

B1> B2>>>>alpha

Direct adrenomimetic

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20
Q

What does Isoproterenol target?

A

B1=B2>>>>>alpha

Direct adrenomimetic

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21
Q

Albuterol targets?

A

B2>>B1>>>>a

Direct adrenomimetic

22
Q

What tissue does alpha1 target? What action occurs?

A
  • vascular smooth muscle
  • pupil dilator muscle
  • prostate
  • heart

Increases contractions of all

23
Q

What tissues does alpha 2 target? What are the actions?

A
  • neurons
    • modulates transmitter release
  • platelets
    • aggregation
  • adrenergic and cholinergic nerve terminals
    • inhibit transmitter
  • vascular smooth muscles
    • contraction
  • fat cells
    • inhibit lipolysis
24
Q

What tissue do Beta1 receptors target? What are the actions?

A
  • Heart juxtaglomerular cells
    • increases force and rate of contraction
    • increases renin release
25
Q

What tissues do B2 target?

A
  • Respiratory,u terine and vascular smooth muscle
    • Promotes smooth muscle relaxation
  • Skeletal muscle
    • promote K uptake
  • Human liver
    • activates glycogenolysis and gluconeogenesis
26
Q

What tissues do B3 target?

A
  • Bladder relaxes detrusor muscle
  • Fat cells activates lipolysis
27
Q

How does epinephrine impact systolic BP and how?

A
  • increases it by effecting B2 and alpha1
  • may decrease diastolic BP and total peripheral vascular resistance
28
Q

How does epinephrine impact respiratory system?

A
  • relaxes bronchial muscle B2
  • Decrease bronchial secretion and congetstion w/n bronchial mucosa A1
29
Q

How does epinephrine impact skeletal muscle?

A
  • causes tremor B2
  • Increases K uptake by skeletal muscle B2
30
Q

How does NE impact cardiac?

A
  • cardiac stimulant that reduces heart rate
  • potent vasoconstrictor
  • increases peripheral vascular resistance and BP
31
Q

Epinephrine increases the concentration of all of the following except?

  • Cyclic AMP in heart
  • Renin in plasma
  • Glucose in plasma
  • Triglycerides in adipocytes
A
  • Triglycerides in adipocytes
  • It actually activates lipolysis
32
Q

What does Phenylephrine cause? What kind of drug is it?

A
  • effective mydriatic and decongestant
  • severe vasoconstriction, BP elevation, and severe bradycardia
  • alpha adrenergic agonists
33
Q

What type of drug is Clonidine and what are it’s effects?

A
  • alpha adrenergic agonists
  • Central effect on presynaptic alpha2 receptors in low brainstem
    • decreasse symp outflow
    • Reduce BP
    • Bradycardia
  • Used to treat HTN
34
Q

What type of drug is Isoproterenol? What are its effects?

A
  • non selective beta agonist
  • Positive inotropic and chronotropic action increases CO via B1
  • Vasodilator decreasing arterial pressure B2
  • Causes bronchodilation B2
35
Q

Dobutamine MOA and receptors?

A
  • Selective B1 agonist
  • Potent inotropic action
  • Less prominent chronotropic action
36
Q

Child swallowed two bottles of nasal decongestant whose primary ingredient is phenylephrine. Signs of OD that may occur include?

  • Mydriasis
  • Bronchoconstriction
  • Tachycardia
  • Vasodilation
  • Sweating
A

Mydriasis due to the alpha receptor agonist

37
Q

What direct acting adrenomimetic (sympathomimetics) drugs are used for hypotensive emergencies such as hemorrhagic shock, OD of anti-HTN, or CNS depressants?

A
  • NE and Phenylephrine
38
Q

What direct acting adrenomimetic (sympathomimetics) are used short term for heart failure?

A

Dobutamine in acute HF

39
Q

What indirect acting adrenomimetic (sympathomimetics) are used in chronic hypotension?

A

Ephedrine

40
Q

What direct acting adrenomimetic (sympathomimetics) drugs are used in cardiogenic shock?

A

Dobutamine

41
Q

What What direct acting adrenomimetic (sympathomimetics) drugs are used for long term HTN treatment?

A

Alpha 2 agonists

42
Q

What direct acting adrenomimetic (sympathomimetics) drugs are used for emergency therapy for a complete AV block and cardiac arrest?

A

Epinephrine and Isoproterenol

43
Q

what are the clinical uses of Phenelzine and Selegiline? What category do they fall into?

A

Depression

They are a type of indirect adrenomimetic drug that inhibits MAO

44
Q

What are the clinical uses for amphetamines and methylphenidate? What category do these drugs fall under?

A

Narcolepsy

Indirect adrenomimetic that reverses NE and DA increasing their release

45
Q

What drug is given for ADHD? What class does it fall under?

A
  • Methylphenidate
  • Indirect adrenomimetic that reverses NE and DA uptake therefore increasing their release
46
Q

What two drugs are given to help treat obesity?

A
  • Ephedrine
  • Amphetamines
47
Q

What two drugs are used for the decongestion of mucous membranes and what category of drug do they fall under?

A
  • Phenylephrine
    • direct acting adrenomimetic alpha agonist
  • Ephedrine
    • indirect adrenomimmetic releasing agent and direct adrenergic receptor agonist
48
Q

What drug is used for examination of the retina to induce mydriasis?

A
  • Phenylephrine
    • direct adrenomimetic alpha agonist
49
Q

What are the AE’s of adrenomimetics?

A
  • Cardiovascular
    • increase BP
    • Increase cardiac work leading potentially to MI or HF
    • Sinus tachy and serious vent arrhythmia
  • CNS
    • insomnina
    • lack appetite
    • anxiety
    • Psychoses
    • Convulsions and hemorrhagic stroke (cocaine)
50
Q

Which tissue will respond to epi but not NE?

  • Ventricular myocytes
  • Dilator muscle of the iris
  • JG cells
  • Bronchial smooth muscle
  • Prostate smooth muscle
A

Bronchial smooth muscle

CPR 2 Exam 1 (21 decks)

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