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CPR 2 Exam 1 > Konorev Adrenergic Drugs Part 1 > Flashcards

Konorev Adrenergic Drugs Part 1 Flashcards

1
Q

What are the direct acting adrenomimetics Alpha agonists?

A
  • Phenylephrine
  • Clonidine
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2
Q

What are the direct acting adrenomimetics mixed alpha and beta agonists?

A
  • Norepinephrine
  • Epinephrine
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3
Q

What are the direct acting adrenomimetic beta agonists?

A
  • Dobutamine
  • Isoproterenol
  • Albuterol
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4
Q

What are the indirect adrenomimetics that inhibit re uptake of DA and NE?

A
  • Cocaine
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5
Q

What are the indir3ect adrenomimetics that inhibit MAO?

A
  • Selegiline
  • Phenelzine
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6
Q

What are the indirect adrenomimetics that increase NE and DA release?

A
  • Amphetamines
  • Methylphenidate
  • Tyramine
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7
Q

What are the indirect adrenomimetic releasing agen and direct adrenergic receptor agonists?

A

Ephedrine

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8
Q

Adrenergic drugs control function of what specific nervous system?

A
  • Sympathetic
  • they mimic or promote effects of NE/E/DA
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9
Q

What do the alpha 1 receptors do intracellularly?

A
  • Increase IP3, DAG
  • they are Gq
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10
Q

What do alpha 2 receptors cause intracellularly to happen? What GPCR type?

A
  • Decrease in cAMP
  • Gi
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11
Q

What do Beta type receptors cause intracellularly? GPCR type?

A
  • increase cAMP
  • Gs
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12
Q

What do dopamine type 1 receptors do?

A

Increase cAMP they are a Gs

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13
Q

What do dopamine type 2 receptors do?

A

Decrease cAMP, they are Gi

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14
Q

Activation of which adrenergic receptor will decreaSe pkA activity in target tissues?

A

alpha 2

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15
Q

Phenylephrine targets what receptor the most?

A

Alpha 1 > Alpha2 >>>>> Beta

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16
Q

Clonidine targets what receptor?

A

alpha 2 > alpha 1 >>>> Beta

Alpha agonists direct adrenomimetics

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17
Q

NE receptor targets?

A

alpha 1 = alpha 2

B1>>B2

Direct adrenomimetic

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18
Q

What receptors does Epinephrine target?

A

alpha1=alpha2

Beta1=Beta2

Direct adrenomimetic

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19
Q

What does Dobutamine target?

A

B1> B2>>>>alpha

Direct adrenomimetic

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20
Q

What does Isoproterenol target?

A

B1=B2>>>>>alpha

Direct adrenomimetic

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21
Q

Albuterol targets?

A

B2>>B1>>>>a

Direct adrenomimetic

22
Q

What tissue does alpha1 target? What action occurs?

A
  • vascular smooth muscle
  • pupil dilator muscle
  • prostate
  • heart

Increases contractions of all

23
Q

What tissues does alpha 2 target? What are the actions?

A
  • neurons
    • modulates transmitter release
  • platelets
    • aggregation
  • adrenergic and cholinergic nerve terminals
    • inhibit transmitter
  • vascular smooth muscles
    • contraction
  • fat cells
    • inhibit lipolysis
24
Q

What tissue do Beta1 receptors target? What are the actions?

A
  • Heart juxtaglomerular cells
    • increases force and rate of contraction
    • increases renin release
25
What tissues do B2 target?
* Respiratory,u terine and vascular smooth muscle * Promotes smooth muscle relaxation * Skeletal muscle * promote K uptake * Human liver * activates glycogenolysis and gluconeogenesis
26
What tissues do B3 target?
* Bladder relaxes detrusor muscle * Fat cells activates lipolysis
27
How does epinephrine impact systolic BP and how?
* increases it by effecting B2 and alpha1 * may decrease diastolic BP and total peripheral vascular resistance
28
How does epinephrine impact respiratory system?
* relaxes bronchial muscle B2 * Decrease bronchial secretion and congetstion w/n bronchial mucosa A1
29
How does epinephrine impact skeletal muscle?
* causes tremor B2 * Increases K uptake by skeletal muscle B2
30
How does NE impact cardiac?
* cardiac stimulant that reduces heart rate * potent vasoconstrictor * increases peripheral vascular resistance and BP
31
Epinephrine increases the concentration of all of the following except? * Cyclic AMP in heart * Renin in plasma * Glucose in plasma * Triglycerides in adipocytes
* Triglycerides in adipocytes * It actually activates lipolysis
32
What does Phenylephrine cause? What kind of drug is it?
* effective mydriatic and decongestant * severe vasoconstriction, BP elevation, and severe bradycardia * alpha adrenergic agonists
33
What type of drug is Clonidine and what are it's effects?
* alpha adrenergic agonists * Central effect on presynaptic alpha2 receptors in low brainstem * decreasse symp outflow * Reduce BP * Bradycardia * Used to treat HTN
34
What type of drug is Isoproterenol? What are its effects?
* non selective beta agonist * Positive inotropic and chronotropic action increases CO via B1 * Vasodilator decreasing arterial pressure B2 * Causes bronchodilation B2
35
Dobutamine MOA and receptors?
* Selective B1 agonist * Potent inotropic action * Less prominent chronotropic action
36
Child swallowed two bottles of nasal decongestant whose primary ingredient is phenylephrine. Signs of OD that may occur include? * Mydriasis * Bronchoconstriction * Tachycardia * Vasodilation * Sweating
Mydriasis due to the alpha receptor agonist
37
What direct acting adrenomimetic (sympathomimetics) drugs are used for hypotensive emergencies such as hemorrhagic shock, OD of anti-HTN, or CNS depressants?
* NE and Phenylephrine
38
What direct acting adrenomimetic (sympathomimetics) are used short term for heart failure?
Dobutamine in acute HF
39
What indirect acting adrenomimetic (sympathomimetics) are used in chronic hypotension?
Ephedrine
40
What direct acting adrenomimetic (sympathomimetics) drugs are used in cardiogenic shock?
Dobutamine
41
What What direct acting adrenomimetic (sympathomimetics) drugs are used for long term HTN treatment?
Alpha 2 agonists
42
What direct acting adrenomimetic (sympathomimetics) drugs are used for emergency therapy for a complete AV block and cardiac arrest?
Epinephrine and Isoproterenol
43
what are the clinical uses of Phenelzine and Selegiline? What category do they fall into?
Depression *They are a type of indirect adrenomimetic drug that inhibits MAO*
44
What are the clinical uses for amphetamines and methylphenidate? What category do these drugs fall under?
Narcolepsy Indirect adrenomimetic that reverses NE and DA increasing their release
45
What drug is given for ADHD? What class does it fall under?
* Methylphenidate * Indirect adrenomimetic that reverses NE and DA uptake therefore increasing their release
46
What two drugs are given to help treat obesity?
* Ephedrine * Amphetamines
47
What two drugs are used for the decongestion of mucous membranes and what category of drug do they fall under?
* Phenylephrine * direct acting adrenomimetic alpha agonist * Ephedrine * indirect adrenomimmetic releasing agent and direct adrenergic receptor agonist
48
What drug is used for examination of the retina to induce mydriasis?
* Phenylephrine * direct adrenomimetic alpha agonist
49
What are the AE's of adrenomimetics?
* Cardiovascular * increase BP * Increase cardiac work leading potentially to MI or HF * Sinus tachy and serious vent arrhythmia * CNS * insomnina * lack appetite * anxiety * Psychoses * Convulsions and hemorrhagic stroke (cocaine)
50
Which tissue will respond to epi but not NE? * Ventricular myocytes * Dilator muscle of the iris * JG cells * Bronchial smooth muscle * Prostate smooth muscle
Bronchial smooth muscle

CPR 2 Exam 1 (21 decks)

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