KINOLONI IN FLUOROKINOLONI Flashcards

1
Q

Kako delimo kinolone in fluorokinolone?

A

4 geneeracije

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2
Q

Kakšni so ti AB?

A

So izrazito močni, širokospektralni, sintetičneg aizbora, uporabljamo za zdravljenje mešanih ali trdovratnih okužb
So na seznamu kritičnega pomena AB.

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3
Q

Kakšen je mehanizem delovanja kinolonov in fluorokinolonov

A

Na gr- bakterijah delujejo na DNK girazo, pri gr+ bakterijah na topoizomerazo IV; na ta način se manifestira BAKTERICIDNO delovanje

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4
Q

KINOLONI 1.GENERACIJE

A

NALIDIKSNA KISLINA, FLUMEKVIN, na aerobne Gr- bakterije, nalidiksna kislina se za zdravljenje ne uporablja več; pomembna pa je kot indikatorska substanca za odkrivanje odpornosti proti kinolonom

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5
Q

KINOLONI 2.GENERACIJE

A

ENROFLUKSACIN, CIPROFLUKSACIN, MARBOFLUKSACIN
Delujejo na Gr+/- in na mikoplazme

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6
Q

KINOLONI 3 GENERACIJE

A

SPARFLUKSACINA, LEFOVLUKSACIN, DANOFLUKSACIN

GR+, GR- tudi na pseudomonas aureginosa

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7
Q

KINOLONI 4.GENERRACIJE

A

KLINAFLUKSACIN, MOKSIFLUKSACIN

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8
Q

FLUMEKVIN

A

Spada med kinolone 1.generacije, deluje na gr- aerobe; uporablja se za kolibacilozo, salmonelozo, pasterolozo

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9
Q

ENROFLUKSACIN

A

Je kinolon oz fluorokinolon 2.generacije; uporablja s eza zdravljenje otitisov povzročen z pseudomonas aureginosa

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10
Q

PRADOFLUKSACIN

A

kinolon 3 generacije za mačke in pse

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11
Q

DANOFLUKSACIN

A

kinolon 3 generacije za respiratorni trakt

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