Kidney Pathology Flashcards
what location do the kidneys develop?
in the pelvis within the 5th week of development
at what week does the kidney ascend to the abdomen?
the kidney ascends into the abdomen by the 9th week of development
what are genitourinary tract anomalies?
Bicornuate uterus and seminal vesicle agenesis
what are the most common complications of renal anomalies?
impaired renal function, infection and calculus formation
renal agenesis is also called?
Potter’s syndrome
Bilateral renal agenesis is predominantly in what gender?
males; it is very rare
what are the sonographic signs of renal agenesis
- kidney and bladder not visualized
- low amniotic fluid
- decreased movement and development
with unilateral renal agenesis, which kidney usually does not develop?
the left kidney
what is typically seen in an ultrasound of unilateral renal agenesis?
- enlargement of contralateral kidney
- 70% genital anomaly
- bicornuate uterus
- seminal vesicle agenesis
what is a supernumerary kidney?
where there is the presence of an extra kidney with its own blood supply and ureter
what is an ectopic kidney?
where one kidney fails to ascend from the pelvis to its proper location during development
typically, where is the ectopic kidney located?
in the pelvis as a palpable mass
Pelvic kidney is prone to…
poor drainage, ureteral reflux, and hydronephrosis
what is a dromedary hump?
a single hump of lobulation on the lateral border of the kidney
what is a horseshoe kidney?
a developmental anomaly that occurs when the kidneys fuse together, creating a horseshoe-shaped structure in the lower abdomen.
where does a horseshoe kidney usually occur?
across the midline, anterior to the aorta
what symptoms can occur with horseshoe kidney?
horseshoe kidney is asymptomatic, but increases the risk for complications such as infection, stones, obstruction, and hematuria
how does horseshoe kidney appear on ultrasound?
a palpable mass anterior to the aorta
what is a hypoplastic kidney?
a hypoplastic kidney is a congenitally small kidney that may be normal or often incompletely developed
what is a duplex kidney?
where the developing kidney is divided into upper and lower sections. the lower section is usually larger
what is the most common renal anomaly?
double collecting system/ duplex kidney
define complete double collecting system
two collecting systems and two ureters that both enter the bladder
define incomplete double collecting system
two collecting systems and two ureters that unite distally before entering the bladder
which part of the kidney typically has problems?
the upper section of the kidney usually shows signs of hydronephrosis
which disease processes are associated with duplex kidney?
obstruction and reflux
duplex kidney is associated with ____ in females?
uterus didelphys (double uterus)
how does duplex kidney appear on ultrasound?
the duplex kidney is usually enlarged, and the renal sinus appears as two echogenic regions separated by normal renal tissue
how do you check for two ureters?
you check for two ureters by seeing if there are two ureters exiting the hilum of the kidney
what is an extrarenal pelvis?
an extrarenal pelvis is a renal pelvis that lies outside the renal sinus
how does an extrarenal pelvis appear on an ultrasound?
it appears as a cystic collection medial to the renal hilum
define ARPKD
Autosomal Recessive Polycystic Kidney Disease. this is found in infants and causes a dilation of the renal collecting tubules in the renal cortex. it is life- threatening.
what is the risk factor for a recessive gene?
it can be very likely to occur if both parents carry the gene for the disease.
what does ARPKD look like on ultrasound?
the cysts are too small to be seen on ultrasound. The kidney appears echogenic.
what is the survival rate of ARPKD?
survival rate is very low, most do not survive for very long.
what is ADPKD?
autosomal dominant polycystic kidney disease
what is the survival rate for a patient with ADPKD?
the survival rate is very high, but 50% of patients develop renal failure by 50 yoa
when do symptoms of ADPKD occur?
by the age of 50
what are the clinical signs of ADPKD?
infection, stones, or cystic rupture
how does ADPKD (PKD) appear on ultrasound?
multiple irregular cysts that consume the kidney’s tissue. the kidneys can also become enlarged. ADPKD can also be associated with liver, pancreas, and splenic cysts
Medullary cystic disease is a _____ gene.
dominant
where are medullary cysts located?
in the medulla of the kidney