kidney function 4

Question 1

how the glomerular filtrate rate controlled externally to the kidneys ?

Answer 1

extrinsic control maintains arterial blood pressure by controlling GFR

Question 2

how is glomerular filtrate rate controlled internally to the kidneys ?

Answer 2

• intrinsic control protects renal capillaries from hypertensive damage and maintain a healthy GFR

Question 3

what activates the sympathetic nervous system

Answer 3

vasoconstricts afferent arteriole = decreased GFR
reduces surface area of filtration barrier via mesangial cells = decreased GFR
stimulates renin release

Question 4

what can cause renin to be released ?

Answer 4

sympathetic activity

Question 5

what does an increase in GFR cause?

Answer 5

cause greater excretion of salt + water and decrease blood volume/ pressure

Question 6

what are the two types of natriuretic peptides ?

Answer 6

• a type secreted from atrial myocardium

- b type secreted from ventricular myocardium

Question 7

what is the action of natriuretic ?

Answer 7

acts on collecting duct cells
inhibits Na entry through epithelial sodium channels
inhibits renin production and aldosterone release

Question 8

what does diuretic do ?

Answer 8

• inhibit ADH release

Question 9

what are some hypotensive effects ?

Answer 9

• decreases blood pressure by systemic vasodilation

increases GFR by dilating afferent arterioles