kidney development

Question 1

embryological origin of kidneys

Answer 1

intermediate mesoderm

Question 2

what else other than kidneys is made from intermediate mesoderm

Answer 2

gonads
mullerian ducts
wolffian ducts
urinary system

Question 3

mesonephric duct is called

Answer 3

wolffian

Question 4

paramesonephric is called

Answer 4

mullerian

Question 5

in the female, the mesonephric duct….

Answer 5

almost completely degrades, just the lower part becomes the ureteric bud

Question 6

in the female, the mullerian ducts become…

Answer 6

oviducts

Question 7

in the male, the mesonephric duct….

Answer 7

forms the ureteric bud and the male reproductive system

Question 8

in the male, the paramesonephric duct…

Answer 8

degenerates

Question 9

the ureteric bud is developed from… and forms…

Answer 9

mesonephric ducts
collecting system - collecting tubules, ureter, major and minor calyces

Question 10

how many embryological kidneys are there and what is the important one

Answer 10

3
metanephric (not mesonephric)

Question 11

ureteriic bud comes into contact with what to form kidney

Answer 11

mesenchyme (from mesoderm)

Question 12

how many collecting tubules in the kidney

Answer 12

1-3 million

Question 13

what does the first bifurcation of the ureteric bud form

Answer 13

major calyces

Question 14

kidney blastema (metanephric bud) becomes

Answer 14

excretory part of kidney - glomerulus, bowman’s capsule, pct, loop of henle, dct

Question 15

where does embryological kidney move from and to

Answer 15

s1-t12

Question 16

why kidney agenesis

Answer 16

failure of ureteric bud to meet the mesenchymal tissue so kidney doesn’t decelop

Question 17

unilateral kidney agenesis incidence

Answer 17

1/1000

Question 18

bilateral kidney agenesis consequences

Answer 18

poor lung development, baby will survive in utero but not after birth

Question 19

what is oligohydramnios

Answer 19

not enough amniotic fluid

Question 20

bifid ureter, a problem?

Answer 20

no

Question 21

what is it called if both poles of teh kidneys fuse

Answer 21

pancake kidney

Question 22

where does horseshoe kidney get stucl

Answer 22

IMA

Question 23

horseshoe kidney incidence

Answer 23

1/500

Question 24

mutations in which proteins cause polycystic kidneys and which modes of inheritance also what goes wrong

Answer 24

polycystin
AD
problems with primary cilia

Question 25

what is ciliopathy

Answer 25

problem with primary cilia. leads to all sorts of cell problems

Question 26

polycystic kidney what is it

Answer 26

large cysts form in the nephron or collecting ducts etc . kidney can become enormous
kidney failure by 60yo in 50%