Key Associations part 4

Question 1

Microcytic anemia

Answer 1

Iron deficiency

Question 2

Autosplenectomy (fibrosis and shrinkage)

Answer 2

Sickle cell disease (hemoglobin S)

Question 3

Bleeding disorder with GpIb deficiency

Answer 3

Bernard-Soulier syndrome (defect in platelet adhesion to von Willebrand factor)

Question 4

Bleeding disorder with GpIIb/IIIa deficiency

Answer 4

Glanzmann thrombasthenia (defect in platelet-to-platelet aggregation)

Question 5

Hereditary bleeding disorder

Answer 5

von Willebrand disease

Question 6

Hereditary thrombophilia

Answer 6

Factor V Leiden

Question 7

DIC

Answer 7

Severe sepsis, obstetric complications, cancer, burns, trauma, major surgery, acute pancreatitis, APL

Question 8

Malignancy associated with noninfectious fever

Answer 8

Hodgkin lymphoma

Question 9

Type of Hodgkin lymphoma

Answer 9

Nodular sclerosis

Question 10

t(14;18)

Answer 10

Follicular lymphoma (BCL-2 activation, anti-apoptotic oncogene)

Question 11

t(8;14)

Answer 11

Burkitt lymphoma (c-myc fusion, transcription factor oncogene)

Question 12

Type of non-Hodgkin lymphoma

Answer 12

Diffuse large B-cell lymphoma

Question 13

1° bone tumor (adults)

Answer 13

Multiple myeloma

Question 14

Age ranges for patient with ALL/CLL/AML/CML

Answer 14

ALL: child,
CLL: adult > 60,
AML: adult ∼ 65,
CML: adult 45–85

Question 15

Malignancy (kids)

Answer 15

Leukemia, brain tumors

Question 16

Death in CML

Answer 16

Blast crisis

Question 17

t(9;22)

Answer 17

Philadelphia chromosome, CML (BCR-ABL oncogene,

tyrosine kinase activation), more rarely associated with ALL

Question 18

Vertebral compression fracture

Answer 18

Osteoporosis

Question 19

HLA-B27

Answer 19

Psoriatic arthritis, ankylosing spondylitis, IBD-associated arthritis, reactive arthritis

Question 20

Death in SLE

Answer 20

Lupus nephropathy

Question 21

Tumor of infancy

Answer 21

Strawberry hemangioma (grows rapidly and regresses spontaneously by childhood)

Question 22

Actinic (solar) keratosis

Answer 22

Precursor to squamous cell carcinoma

Question 23

Herald patch

Answer 23

Pityriasis rosea

Question 24

Cerebellar tonsillar herniation

Answer 24

Chiari I malformation

Question 25

Atrophy of the mammillary bodies

Answer 25

Wernicke encephalopathy (thiamine deficiency causing ataxia, ophthalmoplegia, and confusion)

Question 26

Epidural hematoma

Answer 26

Rupture of middle meningeal artery (trauma; lentiform shaped)

Question 27

Subdural hematoma

Answer 27

Rupture of bridging veins (crescent shaped)