Key Associations Flashcards
1
Q
Actinic (solar) keratosis
A
Precursor to squamous cell carcinoma
2
Q
Acute gastric ulcer associated with CNS injury
A
Cushing ulcer (increased intracranial pressure stimulates vagal gastric H+ secretion)
3
Q
Acute gastric ulcer associated with severe burns
A
Curling ulcer (greatly reduced plasma volume results in sloughing of gastric mucosa)
4
Q
Alternating areas of transmittal inflammation and normal colon
A
Skip lesions (Crohn Disease)
5
Q
Aortic aneurysm, abdominal
A
Atherosclerosis
6
Q
Aortic aneurysm, ascending or arch
A
Tertiary syphilis (syphilitic aortitis), vasa vasorum destruction
7
Q
Aortic aneurysm, thoracic
A
Marfan Syndrome (idiopathic cystic medial degeneration)
8
Q
Aortic dissection
A
Hypertension
9
Q
Atrophy of the mammillary bodies
A
Wernicke encephalopathy (thiamine deficiency causing ataxia, opthalmoplegia and confusion)
10
Q
Autosplenectomy (fibrosis and shrinkage)
A
Sickle cell Disease (hemoglobin S)
11
Q
Bacteria associated with gastritis, peptic ulcer disease, and stomach cancer
A
H.pylorie
12
Q
Bacterial meningitis (adults and elderly)
A
S.pneumoniae
13
Q
Bacterial meningitis (newborns and kids)
A
Group B strep/E.coli (newborns)
S.pneumoniae/N.meningitidis (kids/teens)
14
Q
Bilateral ovarian metastases from gastric carcinoma
A
Krukenburg tumor (mucin secreting signet ring cells)
15
Q
Bleeding disorder with Gp1b deficiency
A
Bernard-Soulier syndrome (defect in platelet adhesion to vWF)
16
Q
Brain tumor (adults)
A
Supratentorial: metastasis, astrocytoma (including glioblastoma), meningioma, schwannoma
17
Q
Brain tumor (kids)
A
Infratentorial: medulloblastoma (cerebellum) or supratentorial:craniopharyngioma
18
Q
Breast cancer
A
Invasive ductal carcinoma
19
Q
Breast mass
A
Fibrocystic change, carcinoma (in postmenopausal women)
20
Q
Breast tumor (benign)
A
Fibroadenoma
21
Q
Cardiac primary tumor (kids)
A
Rhabdomyoma, often seen in tuberous Sclerosis
22
Q
Cardiac manifestation of Lupus
A
Marantic/thrombotic endocarditis (nonbacterial)
23
Q
Cardiac tumor (adults)
A
Metastasis, myxoma (90% in left atrium; “ball and valve”)
24
Q
Cerebellar tonsillar herniation
A
Chiari II malformation
25
Chronic arrhythmia
Atrial fibrillation (associated with high risk of emboli)
26
Chronic atrophic gastritis (autoimmune)
Predisposition to gastric carcinoma (can also cause pernicious anemia)
27
Clear cell adenocarcinoma of the vagina
DES exposure in utero
28
Congenital adrenal hyperplasia, hypotension
21-hydroxylase deficiency
29
Congenital cardiac anomaly
VSD
30
Congenital conjugated hyperbilirubinemia (black liver)
Dubin-Johnson syndrome (inability of hepatocytes to secrete conjugated bilirubin into bile)
31
Constrictive Pericarditis
TB (developing world); idiopathic, viral illness (developed world)
32
Coronary artery involved in thrombosis
LAD>RCA>circumflex
33
Cretinism
Iodine deficiency/ congenital hypothyroidism
34
Cushing syndrome
Iatrogenic (from corticosteroid therapy)
Adrenocortical adenoma (secretes excess cortisol)
ACTH-secreting pituitary adenoma (Cushing Disease)
Paraneoplastic (due to ACTH secretion by tumors)
35
Cyanosis (early, less common)
TOF, TOGV, TA
36
Cyanosis (late; more common)
VSD, ASD, PDA
37
Death in CML
Blast crisis
38
Death in SLE
Lupus nephropathy
39
Dementia
```
Alzheimer's disease
Multiple infarcts (vascular dementia)
```
40
Demyelinating Disease in young women
Multiple Sclerosis
41
DIC
Severe sepsis, obstetric complications, cancer, burns, trauma, major surgery
42
Dietary deficit
Iron
43
Diverticulum in pharynx
Zenker Diverticulum (diagnosed by barium swallow)
44
Ejection click
Aortic stenosis
45
Esophageal cancer
Squamous cell carcinoma (worldwide)
| Adenocarcinoma (U.S.)
46
Food poisoning (exotoxin mediated)
S.aureus, B.cereus
47
Glomerulonephritis (adults)
Berger Disease (IgA nephropathy)
48
Gynecologic malignancy
```
Endometrial carcinoma (MC in US)
Cervical carcinoma (MC worldwide)
```
49
Heart murmur, congenital
Mitral valve prolapse
50
Heart valve in bacterial endocarditis
Mitral>aortic (rheumatic fever)
| Tricuspid (IV drug abuse)
51
Helminth infection (US)
Enterobius vermicularis
| Ascaris lumbricoides
52
Hematoma-epidural
Rupture of middle meningeal artery (trauma; lentiform shaped)
53
Hematoma-subdural
Rupture of bridging veins (crescent shaped)
54
Hemochromatosis
Multiple blood transfusions or hereditary HFE mutation (can result in heart failure, "bronze diabetes", and increase risk of hepatocellular carcinoma
55
Hepatocellular carcinoma
Cirrhotic liver (associated with hepatitis B and C and with alcoholism)
56
Hereditary bleeding disorder
Von Willebrand Disease
57
Hereditary harmless jaundice
Gilbert syndrome (benign congenital unconjugated hyperbilirubinemia)
58
HLA-B27
```
J
Ankylosing spondylitis
s
Psoriatic arthritis
Reactive arthritis
```
Ulcerative colitis
59
HLA-DR3
Diabetes Mellitus
SLE
Graves' disease
Hashimoto thyroiditis
60
HLA DR4
Diabetes Mellitus type 1
| Rheumatoid arthritis
61
Holosystolic murmur
VSD, tricuspid regurgitation, mitral regurgitation
62
Hypercoagulability, endothelial damage, blood stasis
Virchow triad (increase risk of thrombosis)
63
Hypertension, secondary
Renal Disease
64
Hypoparathyroidism
Accidental excision during thyroidectomy
65
Hypopituitarism
Pituitary adenoma (usually benign tumor)
66
Infection secondary to blood transfusion
Hepatitis C
67
Infections in Chronic Granulomatous Disease
S.aureus
E.coli
Aspergillus
*catalase positive
68
Intellectual disability
Down Syndrome
| Fragile X syndrome
69
Kidney Stones
Calcium= radiopaque
Struvite (ammonium)= radiopaque (formed by urease positive organisms such as klebsiella, proteus n S.saprophyticus)
Uric acid=radiolucent
70
Late cyanosis shunt (uncorrected left to right becomes right to left
Eisenmenger syndrome (caused by ASD, VSD, PDA; results in pulmonary hypertension/polycythemia)
71
Liver Disease
Alcoholic Cirrhosis
72
Lysosomal storage Disease
Gaucher Disease
73
Male cancer
Prostatic cancer
74
Malignancy associated with non infectious fever
Hodgkin lymphoma
75
Malignancy (kids)
ALL, medulloblastoma (cerebellum)
76
Metastases to bone
Prostate, breast
Lung
Thyroid
77
Metastases to brain
```
Lung
Breast
Genitourinary
Melanoma
GI
```
78
Metastases to liver
Colon
Stomach
Pancreas
79
Mitochondrial inheritance
Disease occurs in both males and females, inherited through females only
80
Mitral valve stenosis
Rheumatic heart disease
81
Mixed (UMN and LMN) motor neuron disease
Amyotrophic lateral sclerosis
82
Myocarditis
Coxsackie B
83
Nephrotic Syndrome (adults)
Focal segmental glomerulosclerosis
84
Nephrotic syndrome (kids)
Minimal change Disease
85
Neuron migration failure
Kallman syndrome (hypogonadotrophic hypogonadism and Anosmia)
86
Nososcomial pneumonia
S.aureus
Pseudomonas
Other enteric gram negative rods
87
Obstruction of male urinary tract
BPH
88
Opening snap
Mitral stenosis
89
Opportunistic infection in AIDS
Pneumocytis jirovecii pneumonia
90
Osteomyelitis
S.aureus (most common overall)
91
Osteomyelitis in sickle cell disease
Salmonella
92
Osteomyelitis with IV drug use
Pseudomonas
Candida
S.aureus
93
Ovarian tumor (benign, bilateral)
Serous cystadenoma
94
Ovarian tumor (malignant)
Serous cystadenocarcinoma
95
Pancreatitis (acute)
Gallstones, alcohol
96
Pancreatitis (chronic)
```
Alcohol (adults)
Cystic fibrous (kids)
```
97
Patient wit ALL/CLL/AML/CML
ALL:child
CLL: adult >60
AML: adult 65
CML: adult 45-85
98
Pelvic inflammatory disease
C.trachomatis
| N.gonorrhea
99
Philadelphia chromosome t(9;22) (BCR-ABL)
CML
| May sometimes be associated with ALL/AML
100
Pituitary tumor
Prolactinoma, somatotropin adenoma
101
Primary amenorrhea
Turner syndrome (45,XO)
102
Primary bone tumor (adults)
Multiple Myeloma
103
Primary hyperaldosteronism
Adenoma of adrenal cortex
104
Primary hyperparathyroidism
Adenoma, hyperplasia, carcinoma
105
Primary liver cancer
Hepatocellular carcinoma (chronic hepatitis, cirrhosis, hemochromatosis, a1-antitrypsin deficiency, Wilson disease)
106
Pulmonary hypertension
COPD
107
Recurrent inflammation/thrombosis of small/medium vessels in extremities
Buerger Disease (strongly associated with tobacco)
108
Renal tumor
Renal cell carcinoma: associated with Von Hippel-Lindau and cigarette smoking; paraneoplastic syndromes (EPO, renin, PTHrP,ACTH)
109
Right heart failure due to pulmonary cause
Cor pulmonale
110
S3 heart sound
Increased ventricular filling pressure (mitral regurgitation, HF), common in dilated ventricles
111
S4 heart sound
Stiff/hypertrophic ventricle (aortic stenosis, restrictive cardiomyopathy)
112
Secondary hyperparathyroidism
Hypocalcemia of chronic kidney disease
113
Sexually transmitted disease
C.trachomatis (usually coinfected with N.gonorrhea)
114
SIADH
Small cell carcinoma of lung
115
Site of diverticula
Sigmoid colon
116
Sites of atherosclerosis
Abdominal aorta
Coronary artery
Popliteal artery
Carotid artery
117
Stomach cancer
Adenocarcinoma
118
Stomach ulcerations and high gastrin levels
Zollinger-Ellison syndrome (gastrinoma of duodenum or pancreas)
119
t (14;18)
Follicular lymphomas (BCL-2 activation, anti-apoptotic oncogene)
120
t(8;14)
Burkitt lymphoma (c-myc fusion,transcription factor oncogene)
121
t(9;22)
Philadelphia chromosome, CML (BRC-ABL activation, tyrosine kinase oncogene)
122
Temporal arteritis
Risk of ipsilateral blindness due to occlusion of ophthalmic artery; polymyalgia rheumatica
123
Testicular tumor
Seminoma (malignant, radiosensitive)
124
Thyroid cancer
Papillary carcinoma
125
Tumor in women
Leiomyoma (estrogen dependent, not precancerous)
126
Tumor of infancy
Strawberry hemangioma )usually regresses spontaneously by childhood)
127
Tumor of adrenal medulla (adults)
Pheochromocytoma (usually benign)
128
Tumor of adrenal medulla (kids)
Neuroblastoma (malignant)
129
Type of Hodgkin lymphoma
Nodular Sclerosing (vs. mixed cellular it's, lymphocytic predominance, lymphocytic depletion)
130
Type of non-Hodgkin lymphoma
Diffuse large B-cell lymphoma
131
UTI
E.coli
| S.saprophyticus (young women)
132
Vertebral compression fracture
Osteoporosis (type 1: postmenopausal woman; type II:elderly man or woman)
133
Viral encephalitis affecting temporal lobe
HSV-1
134
Vitamin deficiency (US)
Folate (pregnant women are at high risk; body stores only 3 to 4 month supply; prevents neural tube defects)
