Branchial Pouch Derivatives Flashcards
1st pouch
Ears: middle ear cavity, Eustachian tube, mastoid air cells
2nd pouch
Tonsils lining
3rd pouch
3 structures:
Thymus
Left and right inferior parathyroid
4th pouch
Superior parathyroids
Mnemonic
Ear, tonisils, bottom-to-top: 1 (ear) 2 (tonsils) 3 dorsal (bottom for inferior parathyroid) 3 ventral (to=thymus) 4 (top=superior parathyroids)
DiGeorge Syndrome
Failure of 3rd and 4th pouches to develop
T-cell deficiency (thymic aplasia)
Hypocalcemia (failure of parathyroid development)
Associated with cardiac defects
Men 2A
Mutation of Germaine RET (neural crest cells):
Pheochromocytoma (adrenal medulla)
Parathyroid (tumor)
Parafollicular cells (medullary thyroid cancer)
Cleft lip
Failure of fusion of the maxillary and medial nasal processes (formation of primary palate)
Cleft palate
Failure of fusion of the two lateral palatine processes or
Failure of fusion of lateral palatine processes with nasal septum and or median palatine process (formation of secondary palate)