keeping people healthy week 4 Flashcards
What initiates puberty?
puberty starts with the de-inhibition of the pulse generator of the arcuate nucleus
Leptin levels rise in the body throughout childhood and play a part in allowing the arcuate nucleus to resume operation
release of gonadotropin-releasing hormone from the hypothalamus
Pituitary gland secretes FSH and LH
These signal the start of sexual development
Describe puberty in girls
Ages 10-14
ovaries start to produce oestrogen
body matures in preparation for pregnancy
first sign is normally breast development
then hair grows in pubic area and axillae
menstruation usually occurs last
Describe puberty in boys
ages 12-16
sperm and hormone production
testosterone responsible for most changes in the body
puberty begins with testicle and penis enlargement
then hair grows in pubic area and axillae
muscles grow, voice deepens, facial hair develops
What are the first signs of puberty due to?
increased secretion of adrenal androgens, possibly under the influence of adrenocorticotropin hormone
What can cause delayed puberty?
constitutional delay hypogonadotropin hypogonadism chronic illness psychological stress anorexia nervosa excessive exercise endocrine disease
Describe constitutional delay
most common cause of delayed puberty
affected children are healthy and usually more than 2.5 SDs below the median height for their age throughout childhood
often family history
in constitutional delay bone age will be less than chronological age
What effects can delayed puberty have?
in young skeleton oestrogen deficiency leads to increased osteoclast formation and enhanced bone resorption
oestrogen inhibits the differentiation of osteoclasts
the effect is probably mediated by IL1 and IL6
what is a risk factor?
an aspect of personal behaviour or lifestyle, an environmental exposure, or inherited characteristics that on basis of scientific evidence, is known to be associated with meaningful health related conditions
What are risk factors for cardiovascular disease?
smoking alcohol inactivity inappropriate diet genetics mental health diabetes
What is the life course approach?
the study of long term effects on later health or disease risk of physical or social exposures during gestation, childhood, adolescence, young adulthood or later in adult life
What is programming?
the process whereby a stimulus or insult at a sensitive period of time has lasting effect on the structure and function of the body
What is the Barker hypothesis?
the impact of poor foetal nutrition across different sensitive periods results in changes in body structure and function which prepare the baby for austerity
What are the risk factors in the adverse childhood experiences study?
abuse- emotional, physical or sexual
household challenges- mother treated violently, household substance abuse, mental illness in household, parental operation, criminal household behaviour
neglect - physical or emotional
What are the ACE risk factors for?
alcoholism COPD depression foetal death illicit drug use liver disease poor work performance financial stress risk of partner violence STIs smoking suicide unplanned pregnancies risk of sexual violence poor academic achievement
What can adverse childhood experience do?
disrupt neurodevelopment, causes social, emotional and cognitive impairment, adoption of health risk behaviours, disease, disability and morbidity, early death