Karius Autonomics ibook notes Flashcards

1
Q

Movement: the Reflex

A

simplest level of integration between CNS and PNS occurring in the brain

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2
Q

afferent nerve

A

sensory, sends message to CNS about body or environment

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3
Q

efferent nerve

A

moto, sends command to PNS (then to muscles)

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4
Q

Simples reflexes

A

typically have just one synapse (two neurons involved: afferent and efferent) but may have two.

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5
Q

plan of a reflex

A

sensory information causes an AP to be delivered from the pre-synaptic neuron to the CNS where it synapses with a post-synaptic neuron, which initiates an AP down the efferent axon to a target muscle (alpha motor neuron based). Action potential from efferent causes an action potential on the muscle, exciting it and causing contraction.

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6
Q

Do reflexes require the brain to be involved?

A

All reflexes “notify” the brain by having a branch of the first neuron synapse or go to the brain, directly/indirectly

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7
Q

Reflexes in the ANS: part 1

A

the sensory component which is attempting to convey information about sensation internally and externally

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8
Q

Reflexes from the ANS: part 2

A

brain processing information received from ANS, similar to somatic side. this is all the information she has in the ibook on part 2.

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9
Q

the efferent side of ANS: part 3

A

message relayed to effectors (not skeletal muscle) –> smooth muscle and glands.

two parts: sympathetic and parasympathetic system

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10
Q

ANS anatomy, general considerations

A

always has two neurons, two synapses in the pathway going from the spinal cord to the effector organ in the periphery

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11
Q

ANS has how many neurons?

A

Two: one preganglionic (in the CNS) which synapse on a postganglionic neuron (outside the CNS).

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12
Q

ganglion

A

a collection of neuron cell bodies

equivalent of a nucleus in the brain

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13
Q

Pre-ganglionic neuron

A

small, sparsely myelinated B Fiber (relatively slow conduction velocity)

goes from CNS to a ganglion

B-fibers

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14
Q

Post-ganglionic neuron

A

small, unmyelinated type C fiber

C fibers

travels to actual target organ and synapses on that to do the brains command

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15
Q

ANS two divisions

A

sympathetic and parasympathetic

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16
Q

Parasympathetic

A

rest and digestL leave the CNS from the cranium and the sacrum

regardless of where they leave the CNS, the pre-ganglionic axons travel to the ganglion, which is located near the target tissue

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17
Q

Where is the “Ganglion” in the ANS?

A

on or near the target organ

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18
Q

Preganglionic fiber: short or long

A

long, has to be because it leaves from the cranium or sacrum and travels to the post-ganglionic target

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19
Q

Post-ganglionic fiber

A

short, only goes short distance

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20
Q

“PLS” nemonic

A

Parasympathetic, Long, then Short

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21
Q

Sympathetics: preganglionic

A

leave CNS via white rami from thoracic and lumbar regions

22
Q

Preganglionic Sympathetics: regardless where they leave, where do preganglionic sympathetics have to go?

A

they have to go to:
the sympathetic chain
the mesenteric (inferior and superior) ganglia
the celiac ganglia

23
Q

if axons go to the mesenteric or celiac ganglia, when then?

A

they have to pass through the sympathetic chain without synapsing THEN they go to these ganglia and synapse.

24
Q

sympathetics pre ganglia: short or long?

A

short

25
Q

Sympathetic nemonic “SSL”

A

sympathetic, short, long

26
Q

Parasympathetic synapse #1 Where is the ganglia

A

located in the ganglia that are IN/ON/NEAR the target organ

27
Q

Parasympathetic synapse #2 Between what structures

A

between preganglionic axon and the post-ganglionic dendrite

28
Q

Parasympathetic synapse #3 NT

A

NT released by pre-synaptic terminal of the pre-ganglionic cell is acetylcholine

stored in clear vesicles

action is limited by acetycholinesterase bound to the post-ganglionic cell membrane

29
Q

Parasympathetic synapse #4 receptors for NT

A

nAChR 5 subunit receptor, each coded for by a different gene

30
Q

Parasympathetic synapse #5 receptor response

A

nAChR (ligand gated, not voltage gated) –> causes fast ESPS in the post ganglionic cell

31
Q

Parasympathetic synapse #6 Synapse #2

A

between post-ganglionic neuron and the effector (smooth muscle or gland)

32
Q

Parasympathetic synapse: IF smooth muscle is the effector

A

axons travel along smooth muscle and have little bumps called vericosities that contain the ACh and from which they are released, there may be half a dozen of them

33
Q

Parasympathetic synapse: Postganglionic receptor specializations

A

none. there are none. just the nAChRs

34
Q

Parasympathetic synapse: Postganglionic synapse #2 NT on effector

A

AChR —> mAChR

35
Q

Parasympathetic synapse: Effector receptor

A

muscarinic receptor mAChR

36
Q

M2

A

mAChR found on cardiac tissue, connected to Gi protein. activation decreases cAMP and an eventual increase in K conductance

37
Q

M3

A

found on glandular tissues

ACh binding causes increase in IP3, DAG, and an intracellular increase in Ca levels because it is connected to Gq

38
Q

M4

A

receptors are autoreceptors on neurons and control acetylcholine release, they connect to Gi proteins and inhibit adenylate cylcase

39
Q

Gi

A

connect to M2 and M4, inhibit adenylate cyclase

40
Q

Sympathetic: Synapse #1 fast ESPS

A

pre-gang axon synapsing on post-gang dendrite
ACh –> nAChR
fast ESPS

41
Q

Sympathetic Synapse #1 IPSP

A

uses dopamine

released by interneurons within the ganglia

42
Q

Sympathetic: Synapse “slow ESPS”

A

produced by ACh at the M1 receptors, lasts about 30 sec

43
Q

Sympathetic: Synapse #1 “Late, slow ESPS”

A

caused by gonadotropin releasing hormone being used as a neurotransmitter by some pre-ganglionic cells

GnRH (a peptide)

causes late, slow acting ESPS
no all sympathetic synapses show these

44
Q

Sympathetic: Synapse #2 where?

A

between the sympathetic post-ganglionic neuron and effector

norepinephrine (same as noradrenalin) and ATP, neuropeptide Y (particularly if they innervate blood vessels)

vericosities contain granulated densities

45
Q

Sympathetic: Synapse #2 norepinephrine

A

noradrenalin

46
Q

Adrenergic receptors

A

serpentine, metabotropic (connects to a G protein), higher affinity for norepinephrine than epinephrine

two kinds (alpha 1 and alpha 2)

47
Q

Alpha 1 receptor

A

Adrenergic
serpentine, metabotropic (connected to g protein), prefers norepinephrein than epinephrine

has three subtypes
1a, 1b, 1d (1c was reassigned)

48
Q

Sequence of events after Norepinephrine activates an alpha 1 receptor

A

increase IP3, DAG, and eventually to a decrease in K efflux and depolarization

49
Q

Alpha 2 receptor

A

Adrenergic
serpentine, metabotropic (connected to g protein), prefers norepinephrein than epinephrine

has 3 subtypes

2a, 2b, 2c

50
Q

Alpha 2 receptor sequence of events

A

norepinephrine binds

all 3 decrease cAMP and lead to increase of efflux of K and decrease in CA INFLUX

51
Q

beta adrenergic receptor

A

three subtypes, serpentine, have greater affinity for epinephrine than NE but will bind both
metabotropic

binding of NE to beta-adrenergic receptor produces an increase in cAMP