JVD 2018 Malignant Transformation of a Canine Papillomavirus Type 1-Induced Persistent Oral Papilloma Legendre et al Flashcards
What are the three types of papillomabirus which dogs carry?
Taupapillomavirus, Chipapillomavirus, and Lambdapapilloma- virus.
What is the average age of incidence of CPV-1?
2.3 years
What are the suggested causes for non regressing papillomavirus infections?
infection by multiple PV types
cellular immunity defects
humoral immunosuppression
concurrent systemic diseases
What treatments are recommended for non regressing infections?
A multimodal approach is recommended involving:
surgery:electrocautery, scalpel, lasers, or cryo- surgery vaccines: documented but no controlled studies immunotherapy:azithromycin, interferon ⍺-2b, and P acne.
Which two subtypes have the potential to induce OSCC formation?
CPV-1 & CPV-17
With oral CPV-1 what percentage of oral lesions resolve within 2-4 weeks
95%
What are the six steps in the cycle of the oral papilloma virus?
Aquisition
Infection
Multiplication
Viral expression
Viral Assembly
Release
What are some of the cellular immunity defects associated with nonregressive infection?
Defects of keratinocytes, dendritic cells, and Langerhans cells.
What did the presence of CPV-1 DNA in the OSCC suggest?
That the virus might have played a role in the emergence of the OSCC