JVD 2018 Malignant Transformation of a Canine Papillomavirus Type 1-Induced Persistent Oral Papilloma Legendre et al Flashcards

1
Q

What are the three types of papillomabirus which dogs carry?

A

Taupapillomavirus, Chipapillomavirus, and Lambdapapilloma- virus.

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2
Q

What is the average age of incidence of CPV-1?

A

2.3 years

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3
Q

What are the suggested causes for non regressing papillomavirus infections?

A

infection by multiple PV types

cellular immunity defects

humoral immunosuppression

concurrent systemic diseases

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4
Q

What treatments are recommended for non regressing infections?

A

A multimodal approach is recommended involving:

surgery:electrocautery, scalpel, lasers, or cryo- surgery vaccines: documented but no controlled studies immunotherapy:azithromycin, interferon ⍺-2b, and P acne.

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5
Q

Which two subtypes have the potential to induce OSCC formation?

A

CPV-1 & CPV-17

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6
Q

With oral CPV-1 what percentage of oral lesions resolve within 2-4 weeks

A

95%

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7
Q

What are the six steps in the cycle of the oral papilloma virus?

A

Aquisition

Infection

Multiplication

Viral expression

Viral Assembly

Release

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8
Q

What are some of the cellular immunity defects associated with nonregressive infection?

A

Defects of keratinocytes, dendritic cells, and Langerhans cells.

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9
Q

What did the presence of CPV-1 DNA in the OSCC suggest?

A

That the virus might have played a role in the emergence of the OSCC

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