Juvenile Idiopathic Arthritis Flashcards
What is JIA?
- Childhood disease→ swelling, inflamm, pain about jts
- Formerly→ Juvenile Rheumatoid Arthritis (America) and Juvenile Chronic Arthritis (Europe)
JIA Defined:
aka what makes it a JIA dx?
- Arthritis lasting @ least 6wks
- 1 or more jts
- Children <16yo
- WHEN ALL OTHER CAUSES R/O!!!
No neural insult, BUT contractures?
Potential Dx and what to do?
Osteoarthritis?
Refer to ortho!!!
JIA Dx:
- NO true Dx test*
- Mostly clinical and often delayed
- Non-specific signs:
- Mild anemia, elevated erythrocyte sedimentation rate (ESR), radiograph evidence jt swelling, osteopenia
JIA Incidence/Prevalence
Age of onset/gender vary by type
Girls>Boys
JIA Etiology
Unclear BUT…
-
Theory of autoimmune inflammatory disorder:
- External trigger→ trauma, bact/virus
- virus/bacterial infx usually precedes onset
- phys. trauma
Types of JIA:
5:
- Olioarticular (former→ Pauciarticular)
- Polyarticular
- Systemic
- Enthesitis-related
- Psoriatic
Olioarticular JIA
fun fact to KNOW!
Usually one-side only
Olioarticular
- 50-60% cases
- Girls <6yo
- Sx’s:
-
Mild inflamm in 4 or fewer jt→ KNEE MOST COMMON*
- ankles, elbows
- *hip/sm. jts of hands not impacted
- Joints→ swollen, warm, not too painful
-
Mild inflamm in 4 or fewer jt→ KNEE MOST COMMON*
- EXCELLENT PROGNOSIS*
Olioarticular prognosis
EXCELLENT!!!
Polyarticular
*less common
- 25-28%, 5 or more jts
-
Symmetric→ large AND small jts
- MAY include CS and TMJ*
- Jts→ swollen, warm, echymosis
- *Mild systemic sx’s→ low grade fever, hepatosplenomegaly, lymphadenopathy
- Prognosis→ guarded 2* comps: weakness, contractures
Polyarticular prognosis
Guarded (unsure) 2* comps may arise→ weakness, contractures
MOST SERIOUS JIA
SYSTEMIC
Dx marker of Systemic JIA
High fever
Systemic JIA
- 10-12%, MOST serious
- Pain in many jts
- Dx marker==> high fever**
- Rash→ trunk, limbs, face, palms, soles feet
- S/S:
- Pleuritis, pericarditis, myocarditis, hepatosplenomegaly, lymphadenopathy
- Prognosis→ mod-poor: more severe+more jts
Systemic prognosis
Mod-poor bc more severe+many jts
Enthesis-related JIA
- Effects Enthesis→ area where tendons+ligs attach to bone
- jts also maybe affected
Psoriatic JIA
- Combination→ Jt tenderness + inflammation w/ psoriasis of skin OR probs w/ nails
Cardinal signs of Inflammatory Response:
- Swelling, End range stress pain, 2* swelling and protective mm spasms, Jt stiffness, Chronic inflammation==INCd synovial fluid→
- All==> DECd phys activity and low bone density + use of corticosteroids==> INCd fx risk
Cardinal signs of Inflammatory Response:
More on Jt Stiffness
MOST noted upon waking (AM stiff) OR after prolonged sitting
Cardinal signs of Inflammatory Response:
More on Inflamm==> INCd synovial fluid
- Stretches/weaknes jt capsule + adj. structures
- Overgrowth, pannus (see pic), spreads/erodes art. cart.==> changes bone surfaces
- Compromises align, symmetry and stability of jts==> contractures
Medical Mgmt JIA:
Goals→
- Control arthritis, prevent jt erosions, manage extra-articular manifestations
Medical Mgmt JIA:
Coordination w/ drugs
-
NSAIDs→ most widely used first line
- SEs=> GI issues
- dec fever, pain, inflamm→ DO NOT alter dis. course
Medical Mgmt JIA:
Methotrexate (MTX)
- MOST COMMON used to modify dis. itself***
- Children w/ systemic and polyarticular