June11 M1-Chronic Widespread Pain

Question 1

4 areas involved in emotion related to pain (not just pain location)

Answer 1

• periaqueductal grey (beginning of descending mechanism)
• insula (increased connectivity there = more pain in FM)
• thalamus
• cingulate cortex

Question 2

substances that lead to less pain

Answer 2

• NE
• serotonin 1a 1b
• dopamine
• opioids
• cannabinoids

Question 3

substances that lead to more pain

Answer 3

• substance P
• serotonin 2a, 3a
• glutamate and EAA
• nerve growth factor

Question 4

pathology seen in FM

Answer 4

have lacking nerve fibers (typical of small fiber neuropathy which is another disease) in PNS = MORE sensation

Question 5

drug that enhances connection down to periaqueductal grey in FM

Answer 5

SSRIs (antidepressants)