JAUNDICE

Question 1

UNCONJUGATED hyper bilirubinaemia
causes

Answer 1

Crigler-najjar
gilbert

Question 2

crigler najjar pathophysiology

Answer 2

type 1 type 2
absence or decrease of
glucoronyl transferase

Question 3

crigler najjar types

Answer 3

type 1 : AUTO recessive ( absenvce of GT)
type 2: AUTO recessive + pseudodominance( decreased GT)

Question 4

crigler najjar prognosis

Answer 4

only type 2 survive to adulthood
type 1 die in infancy due to unconjugated bilirubinaemia

Question 5

conjugated hyperbilirubinaemia

Answer 5

Dubin jhonson ( auto recessive)
ROTOR syndrome

Question 6

crigler najjar type 1 rx

Answer 6

immediate liver tranplant

Question 7

gilbert syndrome patho

Answer 7

glucoronyl transferase deficiency
same as crigler najjar type 2

Question 8

gilbert syndrome
trigger

Answer 8

self limitting:
fasting
infection
alcohol

Question 9

kernicterus ?

Answer 9

neurological impairement due to bilirubin toxicity
eg type 1
crigler najjar

Question 10

gilbert syndrome labs

Answer 10

all LFT are normal
MILD HIGH UNCONJUGATED BILIRUBIN

Question 11

FLU + Jaundice + NORMAL transaminases =

Answer 11

not hepatitis
but gilbert syndrome

Question 12

cirrhosis labs

Answer 12

abnormal albumin
and
clotting factors