colorectal cancer Flashcards
duke a
no serosal fat , only bowell wall
good5 year prognosis
duke a …
survielance follow up?
colonoscopy
anually… first 2 yrs
then 3rd yearly
duke a
survey occult blood
monthly first 4 yrs
then yearly
col ca bowel habits
may or may not change
col ca blood work and age ?
anaemia + old age
dermoid cyst
females of child bearing age
multiple tissues involved
anaemia : do nothing and reassure
young age +
anaemia resolvable by supplements
> sixty yrs and anaemia
faecal occult blood testing
colonoscopy indication for screening
both 1st and 2nd degree
relatives have cancer
col ca rx
angiogenesis inhibitor
BEVACIZUMAB( VEGF inhibitor)
co ca rx:
CAPE CITA BANE ?
prodrug of 5FLUROURACIL
CAPECITABANE advantage
ORAL BD
…. instead of 5fu iv for 24 hrs
COL CA
METASTASIS indication ???
high CEA levels
meckels diverticulum see ?
technitium scan
col ca METASTASIS RX ??
OXALI PLATIN
Multitherapy
with
5fu +folinic acid
> SIXTY yrs plus anaemia
anaemia evaluation
COLONoscopy
then
upper gi Endoscopy
COL CA
CEA use ?
1=post operative surviellance
2=disease progression
3=diesease free survival rate
col ca … plus …?
in presence of LIVER METS
WHAT disease or syndrome
carcinoid syndrome
HORMONE excess
RX RESECTION WITH METS , OCTREOTIDE AND peptide receptor RT
carcinoid syndrome in COL CA
which hormone ?
neuro endocrine tumor
SERITONIN excess in liver mets
neuro endocrine tumor m/C location
ILEUM
PARAGANGLIOMA
neck
catecholamines secrete 2 percent
tumor of sympathetic nervous system
pheocromocytoma
secrete
adrenaline
loc at adrenal
COL CA and other cancer associations ?
endometrial ca
hnpcc
Endometrial ca in Col ca?
HERIDITORY NON POLYPOSIS COL CA (HNPCC)
ONSET 44 YEARS
men COL CA 0 percent
females col ca 40 percent
AND ALSO
FEMALES : DEVELOP ENDOMETRIAL CANCER 50 PERCENT HIGH CHANCE
COL CA with LIVER mets symptoms
CarCInoiD SYNdrOME
SYSTOLIC MURMUR
PROXYSM ABDOMEN PAIN
DIAHHROEA
FLUSHING
carcinoid syndrome symptoms rx
octreotide
if inaffective
octreotide ineffective in CD symtoms rx
CYPRO HEP TADINE
METHY SER GIDE
Microbial risk for COL CA
STREPtococcus BOVISSS
causes endocarditis ,, murmurs
COL CA query PLUS MURMURS plus fever
endocarditis by streptococcus bovis
strep bovis location
Large bowel
m/c cause of endocarditis generally
staph aureas
COL ca premalignant lesion ?
SERRATED polyps
col ca Bad prognosis not surviellance
depth
RIGHT SIDE location( ascending colon)
cicumference
size
m/c location for Col ca
left side
decending and sigmoid colon
most symptoms
rt side co ca
ascending colon
bad prognosis
less symptoms
Col ca
DUKE A
Bowell wall
NO SEROSA FAT
COLCA duke B
SEROSA involves
Col CA DUKE C….
LYMPH NODES
COL CA DUKE…. DDDD
Distant mets primary to liver
oxaliplatin
muti therapy
non motor neuropathy
only sensory neuropathy
oxaliplatin
NEURO and OTO toxic
NEUTROPENIA
RENAL FUCTION MONITOR in renal impa
platinum therapy fail eg cisplatin ,oxaliplatin col ca rx?
IRINOTECAN