HEP biliary tumors Flashcards
hep cell CA
symptoms
rapid deterioration of liver function and PT{despite taking medications }
anorexia
nausea vomitting
HCC
Lfts?
obstructive( very high ALP)
P..”S”..C with rapid deteriorating LFTs and PT
cholangio ca
Cholangiocarcinoma
Association
primary SCLEROSING cholangitis
cholangiocarcinoma
symptoms
PSC
PAINLESS JAUNDICE
RAISED LFT ( OBSTRUCTIVE )
NORMAL: “AFP”
Ascending cholangitis
symptoms
Fever/rigors
RUQ pain
jaundice
risk factors for
HCC
hepatitis > alcohol
hep c (western countries )
hep b (developing)
percent of HCC resectable
15 to 20 percent
Primary “B”iliary chonangitis
associated disease
haemochromatosis
HCC high prevalence
east africa and south east asia
high in hepatitis
metabolic risk factors for HCC
alpha 1antitrypsisn deficiency
primary or hereditary haemochromatosis (not secondary)
intra and extra hepatic duct dilation causes
PSC
Cholangiocarcinoma
auto immune destruction of INTRA hepatic ducts
PBC
viral hepatitis hepatology
fibrosis and cirrhosis of liver parenchyma
drug indused cholestasis
risk factor
acute or chronic liver disease
drug inused cholestsis drugs
azathioprine
isoniazid
halothane
nsaids
macrolides
tca
other risk factors of HCC
STEATOHEPATITIS ( not hepatic steatosis)
wilson disease
ebstein barr virus CANCER
BURKITTS AND
HODGKINS LYMPHOMAS
CNS
HERPES VIRUS 8 CANCER
KAPOSISARCOMA
HPV cancers
1 and 18
cervical
oral pharengeal and anal malignancies
human t lymphocyte virus cancer
leukaemia
southeast asian / african
hepatomegaly
alcohol
elervated lfts
wt loss
+/- POSITIVE FOR HGEPATITIS
DD?
HCC» CHOLAGIOCARCINOMA
screening for hcc .. whom and when
cirrhosis
six to 12 months
chronic hepatitis b labs
HB s Ag
IgG Anti HB c
acute hepatitis labs
IgM anti HB c
haemangioma of liver USG
Hyper echoic nodular lesions
MILAN criteria for liver transplant
single lesion <=5cm or
three lesion <=3cm with
no extra hepatic involvement and
no major vessel involvement.
coclorectal ca chemo
FOLFOX
CA gall bladdder risk facots
UC
PSC
gall stones
hcc=
cholangio ca=
gall bladder ca=
hallamark
deterirating lft
itchy skin , swingging pyrexia
abdominal mass