DILI Flashcards
DRUG indused *hepatitis vs Autoimmune
history of drug use and abuse
drugs of DILI
ketoconazole
methydopa
isoniazid
nitofurantoin
acitominophen
amox clavum
phenytoin
CHRONIC HEPATITS CAUSES
IBS
WILSON disease
ALPHA 1 antitrisin deficiency
and
all HEpatitis
DILI symptoms
JAUNDICE
HEPATOMEGALY
DILI labs
deranged transaminases
elevated bilirubin
DILI (ANTIBODY) ASSOCIATION
ANTI LKM antibody( also associated with auto immune hepatitis)
pbc lfts
normal transaminases
raised ALP
P s C LFT
RAISED BILIRUBIN
RAISED ALP
mild raised transaminases
co amoxiclav therapy LFT
chole STATIC (RAISED ALP)self limiting not serios
paracetmol
acute liver failure
criteria
ph…………. <7…….3
ORRRR
INR……………. >….six point five +
CREATINE …..>……300 +
grade …3… hepatoencephalopathy
alcoholic hepatitis
LFT
transaminases not exceed >500
ast/alt >2
alcohol units per week for
alcoholic liver failure
more than 14 units
normal recommended units for alcohol per week
14 units
nitrofurantoin induced CHRONIC ACTIVE HEPATITIS
features
normo anaemia pernicious
palmer erythema
spider naevi
joint pains
heparospleenomegaly
elevated bilirubin
elevated ast
DILI
choleSTATIC liver injury
alp higher than others
OESTROGENS
Azathioprine, ciclosporin
CHLORPROMAZINE, HALOPERIDOL
IBUPROFEN /RANITIDINE /CIMETEDINE?CHLORPROPAMIDE
erythromycin/nitrofurantoin/COMOXICLAV/ flucoxacillin
hypoglycemics statins nifedepine
drug induced hepatitis or hepatic injury
static nefidepione
phenytoin carbamazepine
liver cirrhosis drug succeptability for CNS DERANGEMENT
SEDATIVES
opiods
chlorpromazine
bezodiazepines
barbiturates
rate of decline in liver failure
time between jaundice and encephalopathy
<7 is hyperacute failure
mix cholestatic and hepatic liver injury
comoxiclav
sulfasalazine
sulfonamides
carbamazepine
dili heart medicine
amiodarone
alcoholic hepatitis pathology
NECROSIS
