IV fluids & electrolytes & tranfusions Flashcards

1
Q

when would you not use 0.9% saline as fluid replacement?

A
  • ↑ Na+ or ↓ glucose: give 5% dextrose instead
  • ascitic: give human-A- solution (HAS) instead (A- maintains oncotic P, and the Na+ content of saline worsens)
  • ↓ BP<90 shocked: gelofusine (colloid) (has high osmotic content so stays IV)
  • shocked from bleeding: blood transfusion
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2
Q

where to begin when assessing fluid replacement needs?

A

HR, BP, urine output

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3
Q

fluid replacement if ↑ HR or ↓ BP?

A

500ml bolus immediately

(250ml if HF)

then reassess HR, BP, urine output

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4
Q

fluid replacement if only ↓ urine output?
(solely oliguria)
(and not due to BPH)

A

1 litre over 2-4 hrs

reassess HR, BP, urine output

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5
Q

define:

1) anuria

2) oliguria

A

1) 0 ml/hr

2) < 30 ml/hr

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6
Q

predictions of fluid depletion if:

1) ↓ urine output
2) ↓ urine output and ↑ HR
3) ↓ urine output and ↑ HR and shocked (↓ BP)

A

1) 500 ml
2) 1 litre
3) >2 litres

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7
Q

what is the limit to quantity of fluid to prescribe to sick patient?

A

> 2 litres

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8
Q

what does symbol ° mean?

A

number of hours over which a bag of fluid should be given, e.g. 0.9% saline 1 L 2° means 1 L of 0.9% saline over 2 h

in PSA write “2 hours” or “2-hourly” or “2-hrly”

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9
Q

maintenance dose of fluids that adults need over 24 hours?

elderly?

A

3 litres, 2 sweet, 1 salty

  • firstly, 1 litre 0.9% NaCl + 20mmol KCl over 8 hours
  • then 1 litre 5% dextrose + 20mmol KCl over 8 hours
  • again 1 litre 5% dextrose + 20mmol KCl over 8 hours

elderly or very underweight - 2 litres

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10
Q

daily K+ requirements?

A
40mmol KCl (20mmol KCl in two bags)
(IV K+ shouldn't be given at more than 10mmol/hr)
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11
Q

IRL - how to assess pt before giving fluids?

A
  • check patient’s U+E
  • check not fluid overloaded (↑ JVP, peripheral and pulmonary oedema)
  • ensure bladder not palpable (signifies urinary obstruction)
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12
Q

if a patient if hypovolaemic - what do you give?

A

500ml 0.9% NaCl over 15 mins

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13
Q

what to give if a patient is ↓ glucose or ↑ Na+?

A

5% glucose

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14
Q

how much is the maintenance fluid requirement of a 70kg adult?

A

25-30ml/kg per day
so 25 x 70 = 1750
so round it up to two 12 hourly one litre bags

(if they needed 3 litres, 3 x 8 hourly bags)

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15
Q

IMPORTANT what is the max rate of K+ infusion?

A

10mmol/hr

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16
Q

what’s the mmol/kg for addition of KCl or NaCl?

A

1mmol/kg

80kg = 80mmol/24 hours

17
Q

1) how to approach fluid resuscitation?
2) what to give?
3) when to call for help?

A

1) check for causes in Hx/Ex
- D, V, syncope, fluid intake, polyuria, fever, hyperventilation, drain, thirst

2) 500ml 0.9% fluid bolus (250ml if renal impairment/frail/cardiac) <15 mins
3) reassess and repeat <2000ml and CALL FOR HELP if shock or if persistent hypovolaemia even after 2 litres given

18
Q

how is insulin given/route?

A

S/C (not IV!)

19
Q

define acute severe ↑hyperkalaemia?

A

> 6.5 mmol/l or in the presence of ECG changes

20
Q

Tx acute severe ↑hyperkalaemia? (4)

A

1) 10-20ml calcium gluconate 10% by slow IV injection (cardioprotective)
2) 10 units actrapid IV
3) 100ml of 20% IV dextrose
4) nebulised salbutamol 10mg

21
Q

causes ↓hypokalaemia?

“DIRE”

A

D - diuretics (loop, thiazide)
I - inadequate intake or intestinal loss
R - renal tubular acidosis
E - endocrine (Cushings/Conns)

22
Q

causes ↑hyperkalaemia? (4)

“DREAD”

A
D - diuretics (ACEi + K+ sparing)
R - renal failure
E - endocrine (Addison's)
A - artefact
D - DKA
23
Q

if someone has ↓↓↓↓ BP, what do you give first?

A

fluids FIRST stat

then consider blood transfusion

24
Q

when to transfuse a patient with Fe def anaemia? (2)

A

1) if severely Sx, eg angina, and can’t wait for Fe replacement to kick in
2) Hb <70g/L

25
Q

how much does Hb usually rise per week on Fe replacement therapy?

A

10/g/L/week

26
Q

how long to give oral Fe for ↓Hb?

A

until Hb is normal

then 3 months thereafter

27
Q

Tx AKI?

A

cannula + catheter, fluid monitoring
IV fluid 500ml stat, 1 litre 4 hrly
cause: bloods, ABG, DHx, US kidneys, urinalysis

check for life threatening complication:

1) pulmonary oedema/fluid overload
2) ↑K+
3) acidosis

28
Q

what to write as insulin prescription for acute ↑K+?

A

“10 units Actrapid in 100ml of 20% dextrose, over 30 min”

IV

29
Q

effect of LMWH on K+?

A

Dalteparin (and all heparins) can contribute to hyperkalaemia

30
Q

some drugs that ↓Na+?

A

bendroflumethiazide

citalopram (SSRIs) -SIADH

31
Q

what fluids to give patient who has received 2L bags of NaCl 0.9% in 24 hours, with 20mmol K+ in each, is NBM, 80kg, and normoglyaemic?

A

glucose 5%/potassium chloride 0.3% solution

  • risk of NaCl overload - 154 mmol Na and Cl in each bag (80 kg = 80 mmol/day
  • requires K+ (only 40mmol; requires 80mmol for maintainence)
  • normoglycaemic and euvolaemic; hydrate using 5% glucose
  • 2000–2400 mL/day (80-100 mL/h)
  • the ideal infusion rate is 1 L over 8-12 h using a bag containing 0.3% (40 mmol/L) potassium
32
Q

how to ensure 40mmol/litre K+ in 12 hours?

A

infuse 1 L over 8-12 h using a bag containing 0.3% (40 mmol/L) potassium

(diluted by 10 - KCl 3% 40mmol/100ml 100ml bag)

33
Q

if recovering from AKI, fluid output (6 litres) is double input (3 litres), only able to tolerate 500ml oral intake, Na+ is higher end of normal and K+ is a little low?

A
  • as part of recovery, patients may enter a ‘polyuric phase’ in which their urine output increases and fuid input may not keep pace, resulting in dehydration and electrolyte abnormalities
  • urine output exceeding 200mL/h should always prompt consideration of this

1 simple rule: input should be similar to output (allowing 10–15% difference)

  • if 250mL/hour (6L in 24 hours), oral intake of 500mL is inadequate
  • low K+ and Na+ at the upper end of normal
  • THEREFORE 5% dextrose with 20mmol KCl
  • patient is losing 1L every 4hours (24/6)
  • input should match, so a 1L bag over 4hours best
34
Q

patient admitted to hospital 7 hours after an acute stroke, unwell for 2 days and eating and drinking less than usual, PMH -HT (on ramipril), alert, dysphasic and has a right hemiparesis, unable to swallow and does not tolerate insertion of a nasogastric tube.

Na+ 144 mmol/L (137–144)
K+ 3.9 mmol/L (3.5–4.9)
U 7.5 mmol/L (2.5–7.0)
Cr 85 µmol/L (60–110)
Random plasma glucose 7.2 mmol/L

ONE IV fluid that is most appropriate for the patient at this stage?

A
  • sodium chloride 0.9%/potassium chloride 0.15% solution
  • 500 mL over 4-6 h or 1 L over 8-12 h. **faster dangerous (K+ in this bag)
  • 15% KCl is 20mmol/10ml
  • therefore 0.15% KCl is 0.2mmol/10ml (so 20mmol would be a 1 litre bag)
  • ***WHY NaCl even though Na+ high??
  • patient is unable to hydrate or nourish themselves, so requires maintenance IV water, electrolytes and nutrition
  • patient may be fluid depleted (not been eating and drinking for 2 days) (causes ↑ Na+ and urea, but BP and HR okay)
  • NaCl is a major component in initial IV fluid Tx to maintain extracellular volume and make up for any deficit
  • should contain K+ as well (1 mmol/kg/day)
  • no need for rapid fluid replacement as the patient is not in need of resuscitation

***WHY NOT GLUCOSE?
Patient will require some nutritional support (glucose) in the first 24 hrs.
BUT, glucose-containing fluids have the potential to EXACERBATE cerebral injury

(so this would not be a good choice of initial fluid replacement (the current glucose is elevated)

35
Q

when is compensation for potassium loss is especially necessary?

A
  • digoxin or anti-arrhythmic drugs (↓ K+ may induce arrhythmias)
  • secondary hyperaldosteronism (↑aldosterone AND ↑ renin):
  • RAS, cirrhosis, nephrotic syndrome, severe HF
  • excessive losses of K+ in the faeces, e.g. chronic D associated with intestinal malabsorption or laxative abuse
36
Q

Alcohol dependent patient is disorientated, irritable and confused. Temperature 37.3°C, HR 104/min and rhythm regular, BP 116/86 mmHg, O2 sat 98% breathing air. Jaundiced, marked tremor of the hands. Abdominal examination reveals 3 cm tender hepatomegaly with no evidence of shifting dullness on percussion.

↓ Na+ 133 mmol/L (137–144)
↑ K+ 3.7 mmol/L (3.5–4.9)
↑ U 2.6 mmol/L (2.5–7.0)
Cr 76 µmol/L (60–110)
↓ albumin 28 g/L (37–49)
↑ bili 86 µmol/L (1–22)
↑ ALT 450 U/L (5–35)
↑ ALP 188 U/L (45–105)
BM 5.1 mmol/L.
A
  • vitamin B substances with ascorbic acid (Pabrinex® I/V High Potency) 2 pairs (10 mL) by IV infusion over 30 mins 8-hrly
  • prophylactic for Wernicke’s encephalopathy
  • ***Why not NaCl +/- KCl??
  • eg potassium chloride 0.3%/sodium chloride 0.9% infusion 1 L IV over 2 h
  • would provide an excessive rate of delivery of K+ and this Na+ load would be unwise in a patient with impaired liver function
37
Q

drugs that ↑K+?

A

spirinolactone (and amiloride)
ACEi
ARBs

trimeth
NSAIDs
ciclosporin

38
Q

drugs that cause ↓K+?

A

thiazide
loop
laxatives
salbutamol

theophyll
steroids
mineralocorticoids
aminoglyc
amphotericin B
insulin
liquorice
39
Q

drugs causing ↓Na+

A

thiazide
loop
ARBs
ACEi

carbamaza
PPIs
SSRIs
sulfonylurea
venlafaxine