Enzyme inhibitors/inducers Flashcards
1
Q
↑ enzyme activity + ↓ drug concentration?
(inducers)
“PC BRAS”
A
PC BRAS
P henytoin C arbamazepine B arbiturates R ifampicin A lcohol (chronic) S ulphonylureas
2
Q
↓ enzyme activity + ↑ drug concentration?
(inhibitors)
“AODEVICES”
A
AODEVICES
A llopurinol O meprazole D isulfiram E rythromycin V alproate I soniazid C iprofloxacin E thanol (acute) S ulphonamides
3
Q
P450 inhibitors?
“SICKFACES.COM-group”
A
Sodium valproate Isoniazid Cimetidine Ketonazole Fluconazole Alcohol (binge) Chloramphenicol Erythromycin Sulfonamides (i - inhibitor) . Ciprofloxacin OMEPRAZOLE METRONIDAZOLE - Grapefruit juice
4
Q
P450 inducers?
CRAP-GPS
A
CRAP-GPS induces me to madness
Carbamazepines Rifampicin Alcohol (chronic) Phenytoin Griseofulvin Sulphonylurea (u - inducer)