Antihypertensives Flashcards

1
Q

ACEi S/E

A

↓Na+ and ↑K+

  • dry cough
  • AKI (beware RAS) (creatinine transiently rises <20% from baseline)
  • postural hypotension
  • angioedema (afro-american)
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2
Q

CCB S/E

A

flushing
peripheral oedema
severe bradycardia with B-blocker (verapamil)

(avoid in biventricular HF)

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3
Q

B-blockers S/E

A
wheeze in asthmatics
worsening HF
fatigue
nightmares
cold extremities
severe bradycardia (verapamil)

avoid in PVD

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4
Q

diuretics S/E

A
  • hypo K+ and Na+
  • if K+ sparing, HYPER K+ and gynaecomastia
  • (gout - loop diuretics “furosemide”)
  • AKI/renal failure
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5
Q

main 3 categories of anti-HT S/Es?

A

1) hypotension
2) ↓ HR with B-blockers + some CCBS // or electrolyte disturbance with ACEi + diuretics
3) individual specific S/E

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6
Q

effect of loop and thiazide diuretics on K+?

A

↓ K+
(↑ K+ excretion via kidneys)

don’t give two loops together!

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7
Q

effect of ACEi on K+?

A

↓ aldosterone production + thus ↓ K+ excretion in the kidneys

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8
Q

effect of ACEi with NSAID?

A

can lead to RF

NSAIDs ↓ prostaglandin synthesis which ↓ renal artery diameter (and ↓ blood flow)

thereby ↓ kidney perfusion and function

ACE-i ↓ angiotensin-II production necessary for preserving glomerular filtration when the renal blood flow is ↓

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9
Q

S/E that all diuretics can have in common?

A

↓ Na+

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10
Q

important S/E of amlodipine (CCB)?

A

peripheral oedema

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11
Q

can you prescribe verapamil alongside a B-blocker?

A

no! due to the risk of

1) ↓ HR (or at worst asystole)
2) ↓ BP

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12
Q

antihypertensives contraindications?

A

hypotension
bradycardia
cough
renal distrurbance

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13
Q

what is the pathway for prescribing antihypertensives?

A

A=ACEi/ARB
C=CCB
D=thiazide-like diuretic

1) <55 A, >55 or black C
2) A+C
3) A+C+D
4) A+C+D+further D+B-blocker

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14
Q

when to avoid ACEi?

A

RAS
PVD (CLI)
GFR<30
↑ K+

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15
Q

what time of day best to give ACEi?

A

at night

postural hypotension

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16
Q

ARBs S/E

A

↑ K+

-sartans

17
Q

names of CCBs? (4)

A

verapamil
diltiazem
amlodipine
nifedipine

18
Q

how to monitor effectiveness when patient is on diuretics?

A

weight

19
Q

if patient has rise in creatinine after starting ACEi?

A

continue ACEi, repeat U+E after 1 week

small rise in creatinine (<20%) is to be expected when starting ACEi (Ix or change not needed)

20
Q

when put on high dose diuretics: what to bear in mind?

A

1) renal function (esp if they become ill/dehydrated)
2) time of day given - often weeing for 4-6 hours after
3) BP (Sx of collapse?)

21
Q

if ACEi given to black pt?

A

angioedema (give ARBs)

22
Q

S/E spirinolactone?

A

more K+

gynaecomastia