ITE CA2 Local anesthetics

Question 1

ester LA metabolism

Answer 1

pseudocholinesterase

Question 2

amide LA metab

Answer 2

liver

Question 3

ester allergic metabolite

Answer 3

para-aminobenzoic acid (PABA -> breakdown product of ester metabolism)

Question 4

amide allergic megabolite

Answer 4

methylparaben (preservative)

Question 5

nerve c fiber

Answer 5

no myelin, slow conduction, dull pain, temp, increased sensitivity to local anesthetics

Question 6

nerve a-delta

Answer 6

MYELINATED, HAVE AN INTERMEDIATE CONDUCTION SPEED AND TRANSMIT SHARP PAIN AND TEMPERATURE SENSATION

Question 7

Local anesthetics ionized form protonated or not?

Answer 7

ionized (protonated)
nonionized forms (base or nonprotonated)

Question 8

pKa effect on LA placental transfer

Answer 8

The pKa value for local anesthetics is important for transport across the placenta because the drugs can freely pass through the placenta while in the nonionized state. The pKa is the pH at which a drug has equal concentrations of ionized (protonated) and nonionized forms (base or nonprotonated).