IS HLAs

Question 1

HLA-B27

Answer 1

Ankylosing Spondylitis

Reiter’s syndrome

Juvenile RA

Question 2

HLA-DR4

Answer 2

RA
IgA neuropathy
Type 1 diabetes

Question 3

HLA-DR3

Answer 3

Sjorgen’s syndrome
Gluten Sensitive Enteropathy
Chronic active hepatitis
Dermatitis Herpetiformis
Idiopathic membranous glomerulonephritis
Grave’s disease
Dermatitis Herpetiformis

Question 4

HLA-DR2/DR3

Answer 4

SLE

Question 5

HLA-B5

Answer 5

Ulcerative colitis

Question 6

HLA-A3, B14

Answer 6

Idiopathic Hemochromatosis

Question 7

HLA-DR5

Answer 7

Pernicious anemia
Hashimoto’s disease

Question 8

HLA-B13, HLA-Cw6

Answer 8

Psoriasis Vulgaris

Question 9

HLA-B5

Answer 9

Bechet’s Disease

Question 10

HLA-Dw3

Answer 10

Addison’s disease

Question 11

HLA-B8

Answer 11

Myasthenia gravis

Question 12

HLA-DR2

Answer 12

Multiple sclerosis

Question 13

HLA-A28

Answer 13

Schizopernia

Question 14

Mediator of innate immune response

Answer 14

IL-1

Question 15

Acts as antagonist to IL-1 by blocking the IL-1 receptor and limiting availability of the receptor for IL-1

Answer 15

IL-1RA

Question 16

Principal mediator of the acute inflammatory response to GN bacteria

Answer 16

TNF

Question 17

Cachectin
Most prominent member of TNF

Answer 17

TNF-A

Question 18

TNF-A is secreted by

Answer 18

activated monocytes and macrophages

Question 19

Lymphotoxin

Answer 19

TNF-B

Question 20

Factors that induced growth arrest in tumor cells

Answer 20

TGF-B

Question 21

Interfere with viral replication process in an infected cells

Answer 21

Interferon

Question 22

IFN-a is produced by

Answer 22

Mononuclear phagocytes

Question 23

IFN-b is produced by

Answer 23

Fibroblast and epithelial cells

Question 24

IFN-Y is produced by

Answer 24

TH1 cells

Question 25

Antagonist to IL-4
Major macrophage activator
Stimulates antigen presentation by Class II MHC

Answer 25

IFN-Y

Question 26

Drives the growth and differentiation of both T and B cells and induces lytic activity in NK cells
T-cell growth factor

Answer 26

IL-2

Question 27

Responsible in allergic reaction, parasitic infections, and auto immune disease

Induces T-CELL PROLIFERATION

Answer 27

IL-4

Question 28

Inhibits production of pro-inflammatory cytokines by mononuclear phagocytes

Inhibits the accessory functions of mononuclear phagocytes for T cells activation

acts as an antagonist of IFN-Y

Answer 28

IL-10

Question 29

Induces hematopoiesis

Answer 29

IL-3