Ionophores Flashcards

1
Q

Ionophores are classified as the “______ ____” by the FDA without any human use.

A

“antimicrobial drug”

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2
Q

Small amounts of ionophores can hurt the (species)

A

horse

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3
Q

____ are classified as abx by altering the microbial composition of the (body system)

A

Ionophores; GI tract

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4
Q

Ionophores uses:

A
  • Better feed efficiency in cattle
  • help control coccidia but will not tx
  • Rumensin- used in feedlot to control acidosis and bloating
  • improve energy or storage of fat or increased milk prod. in dairy cattle
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5
Q

Ionophore toxic syndrome, what is it?

A

Excessive ionophore conc. affecting host cells, which may result in Pulm, congestion and moderate interlobular edema, pleural effusion, cardiac necrosis, meningeal congestion

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6
Q

Monensin toxicity in cattle clinical signs

A

Heart and skeletal muscles degenerate, necrosis and mineralization- acute death with increased exercise/excitement/stress bc toxicity of the heart muscles

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7
Q

____ is ten times more toxic than lasolocid (used for feed efficacy)

A

Monensin

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8
Q

Toxicity of ionophores on necropsy:

A

Pulm, congestion and moderate interlobular edema, pleural effusion, cardiac necrosis, meningeal congestion

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9
Q

Diagnosis of Ionophore toxicity:

A

Cardiotrophin test to test heart enzyme levels (will be increased).
UPenn School test of serum to detect the monensin in the blood

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10
Q

What are the names of the ionophores used on cattle farms to increase feed? Which one is more potent???

A

Monensin (Rumensin), Bovatec (lasalcoid); Monensin/Rumensin is 10x more potent

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