Ionophores

Question 1

Ionophores are classified as the “______ ____” by the FDA without any human use.

Answer 1

“antimicrobial drug”

Question 2

Small amounts of ionophores can hurt the (species)

Answer 2

horse

Question 3

____ are classified as abx by altering the microbial composition of the (body system)

Answer 3

Ionophores; GI tract

Question 4

Ionophores uses:

Answer 4

• Better feed efficiency in cattle
• help control coccidia but will not tx
• Rumensin- used in feedlot to control acidosis and bloating
• improve energy or storage of fat or increased milk prod. in dairy cattle

Question 5

Ionophore toxic syndrome, what is it?

Answer 5

Excessive ionophore conc. affecting host cells, which may result in Pulm, congestion and moderate interlobular edema, pleural effusion, cardiac necrosis, meningeal congestion

Question 6

Monensin toxicity in cattle clinical signs

Answer 6

Heart and skeletal muscles degenerate, necrosis and mineralization- acute death with increased exercise/excitement/stress bc toxicity of the heart muscles

Question 7

____ is ten times more toxic than lasolocid (used for feed efficacy)

Answer 7

Monensin

Question 8

Toxicity of ionophores on necropsy:

Answer 8

Pulm, congestion and moderate interlobular edema, pleural effusion, cardiac necrosis, meningeal congestion

Question 9

Diagnosis of Ionophore toxicity:

Answer 9

Cardiotrophin test to test heart enzyme levels (will be increased).
UPenn School test of serum to detect the monensin in the blood

Question 10

What are the names of the ionophores used on cattle farms to increase feed? Which one is more potent???

Answer 10

Monensin (Rumensin), Bovatec (lasalcoid); Monensin/Rumensin is 10x more potent