Ion Channels

Question 1

Key experimental technique used to measure current flow through ion channels

Answer 1

Patch clamp
Planar Lipid bilayer techniques

Question 2

Electrophysiological recording

Answer 2

Measurement of ionic currents involved in cellular functions

Question 3

Patch clamp

Answer 3

Direct recording of Ionic currents from cell surface ion channels

Question 4

Planar lipid bilayer technique

Answer 4

Direct recording of ionic currents from intracellular ion channels.

Used for voltage clamp recordings

Question 5

Probability of channel gating

Answer 5

Topen / Tclosed

Question 6

What represents the process of channel gating ?

Answer 6

Kinetic models

Question 7

Single channel conductance

Answer 7

How good a channel is at letting current through

Question 8

Channel inhibitors

Answer 8

Tetrodotoxin
Tetraethylammonium

Question 9

Tetrodotoxin

Answer 9

Na+ channels

Question 10

Tetraethylammonium

Answer 10

K+ channels

Question 11

Malignant hyperthermia

Answer 11

Ryanodine receptor type 1 channel mutations