Introduction to Inflammation Flashcards
What are some causes of erythema nodosum?
Viral illness
Drug reaction
OCP
How does stenosis differ in giant cell arteritis cf to artherosclerosis?
GCA is a more smooth, tapered stenosis
What are some negative acute phase reactants?
Albumin
Hb (more chronic)
What are the target tissues and antigens in ANCA?
Kidney’s
Lungs
Sinuses
Cytoplasmic component of neutrophils
What are the two commonest way coeliac’s presents (non-symptoms)?
Fe deficient anaemia
Hypoalbuminea secondary to malabsorption
What rash is rarely present in coeliac’s?
Dermatitis herpatiformis
What is the commonest vasculitis?
Giant cell arteritis
What is distinct about malar rashes?
Sparing of the nasolabial fold
What are the target tissues and antigens in Grave’s disease?
Thyroid
TSH receptor, TPO, thyroglobulin
To what targets are antibodies produced against in lupus?
Ro (SSA) and La (SSB) - ribonucleoproteins
dsDNA
snRNP core protein
Thrombin
Histones
What is giant cell arteritis aka?
Temporal cell arteritis
What is the target tissues and antigen in RA?
Synovial membrane
IgM Fc
What are the target tissues and antigens in Goodpasture’s?
Kidney, lungs
Type 4 Collagen (basement membrane)
What is the biggest risk factor for the development of autoimmune disease?
Advancing age
Does vasculitis preferentially effect arteries or veins generally?
Arteries
