Introduction Flashcards
What is afterload?
The pressure the heart pumps against
Afterload increases with increased vascular resistance. How does vascular resistance relate to vessel diameter?
Increased vessel diameter
Increased resistance
Increased afterload
What type of drug is atropine and what does it do?
Anti-cholinergic
Positive inotrope (contractility) and dromotrope (increased AV node conduction)
Used for bradyarrhythmias
What is cardiac tamponade? What type of heart failure is it associated with?
Fluid in the pericardium causing pressure on heart chambers
Right sided congestive heart failure
What are the 4 treatments for CHF in order of importance?
Loop diuretic - furosemide/torasemide
Pimobendan (PDE III inhibitor)
ACE inhibitor - benazepril
Spironolactone
What type of drug is digoxin? What is it used for?
Negative chronotrope (class V)
Weak positive inotrope
Used for tachyarrhythmias
What is difference between furosemide and spironolactone in terms of effusions?
Furosemide better for pulmonary oedema
Spironolactone better for pleural and abdominal effusions
What is forwards heart failure?
Systolic failure
What is backwards heart failure?
Congestive heart failure
Inability to cope with preload
What are the two types of hypertrophy? What causes them and how do they affect the myocardium and heart size?
Concentric - pressure overload, myocardial hypertrophy
Eccentric - volume overload, increased chamber size
What are the 5 classes of negative chronotropes?
Class I - block sodium (quinidine, lidocaine)
Class II - Beta blockers (atenolol)
Class III - block potassium channels (sotalol)
Class IV - block calcium channels (diltiazem, amlodipine - used for high BP)
Class V - miscellaneous, digoxin
What type of drug is pimobendan and what effects does it have on the heart and blood vessels?
PDE III inhibitor
Positive inotrope
Vasodilator
What is pulsus paradoxus?
Dramatic drop in stroke volume and blood pressure during inspiration
(Drop >10mmHg)
Seen with cardiac tamponade and respiratory conditions
What type of drug is terbutaline? What does it do?
Beta 2 agonist
Positive chronotrope and dromtrope
Used for bradyarrhythmias
What drugs can be used to treat bradyarrhythmias?
Atropine
Glycopyrrlate
Terbutaline