Intro to Pharm Definitions Flashcards
Drug
substance that brings about a biological change in function through its chemical actions
FDA role
ensure drugs are safe and effective
Pro-drug
drug that must be converted to it’s active form once inside the body
Pharmacotherapeutics
field of study of appropriate use of medications to treat or prevent disease and manage symptoms
Pharmacogenomics
field of study of genetic impact on drug metabolism or processes that can affect individual responses to drugs
Pharmacoeconomics
field of study utilizing scientific and economic methods to evaluate and compare value between therapies
Pharmacoepidemiology
field of study that applies epidemiological principles and methods to study uses and effects of meds on large populations
beta blocker nomenclature
-lol, ex: propranolol, atenolol, metoprolol
alpha blocker nomenclature
-sin, ex: doxazosin, prazosin, terazosin
ACE Inhibitor nomenclature
-pril, ex: benazepril, lisinopril, captopril
Calcium channel blocker nomenclature
-pine, ex: amlodipine, felodipine, nifedipine
Diuretic nomenclature
-ide, ex: hydrochlorothiazide, furosemide
H2 Receptor antagonist nomenclature
-ine, ex: ranitidine, nizatidine, cimetidine
Proton pump inhibitor nomenclature
-zole, ex: omeprazole, esomeprazole
Duration of action definition
time period between onset of drug effect and end of effect
Therapeutic window definition
ratio between minimum effective concentration and minimum toxic concentration
Four classifications of chemical interactions
additive, synergistic, potentiation, antagonism
Definition of functional antagonism
two agonists interact with different receptors to produce an opposite effect
Definition of chemical antagonism
drug counters the effect of another resulting in decreased effect
Definition of dispositional antagonism
metabolism of a chemical is altered and concentration and/or duration of chemical are diminished
Definition of receptor antagonism
receptor configuration/specificity
Therapeutic equivalence definition
must be pharmaceutically equivalent and it is expected to have the same clinical effect and safety profile
Bioequivalence definition
similar rate and extent of absorption, 80-125% of reference product
Pharmaceutical alternatives definition
same drug but different salts/complexes, or different dosage forms/strengths
“A” Codes for therapeutic equivalence
drug products that are considered to be therapeutically equivalent to other pharmaceutically equivalent products
“B” codes for therapeutic equivalence
drug products that FDA is considered not to be therapeutically equivalent to other pharmaceutically equivalent products
gm or g
grams
mg
milligrams
mcg
micrograms
mEq
milliequivalents
lb
pounds
kg
kilograms