Intro to Immunology-Diebel Flashcards
What type of antibody is secreted?
IgA (secretory IgA–sIgA)
Which cell type is the first contact with an invading organism?
macrophages
Which cell type first attacks an invading organism?
neutrophils
Toll-like receptors
located on phagocytic antigen-presenting cells
bind to PAMPs
PAMP
pathogen-associated molecular patterns
ie flagella, LPS, etc.
Phagolysosome function
phagocytize bacteria, present antigens on MHC-II
TLR3 binding molecule
dsRNA
IRF3
transcription factor in TLR3 cascade
NFkB
transcription factor in TLR3 cascade
What is the basic molecular basis of complement?
enzyme cascade in serum that binds to invading organisms and facilitates phagocytosis
What are the myeloid precursor derivatives?
macrophages, dendritic cells, neutrophils, mast cells
What are the lymphoid precursor derivatives?
T-cell, B-cell (–>plasma cell)
Myeloid precursors give rise to this class of cells
antigen presenting cells
Opsonization
promotes binding of PAMPs to TLR favorable
What type of infection does interferon help fight?
viral
Where do B-cells mature?
marrow
Where do T-cells mature?
thymus
What is the major difference between cytokine and hormone release?
cytokines are produced only in response to infection and are not generally stored
Chemokines vs cytokines
chemokines are subtype of cytokines that attract cells into inflamed tissues and play a role in leukocyte homing
Chemokines vs cytokines
chemokines are subtype of cytokines that attract cells into inflamed tissues and play a role in leukocyte homing
Type 1 interferons are produced by
viral infected cells
Type 2 interferons are produced by
activated T-H1 cells through antigen
T/F B-cells need to be present at site of infection to be effective
F
T/F T-cells need to be present at site of infection to be effective
T
How do antibodies re-link the adaptive immune system with the innate immune system?
antibodies are produced by B-cells
phagocytic cells of innate immune system recognize Fc region of antibodies bound to bacteria and phagocytize the organism
Active immunity
acquired from infection, results in memory cell formation
Passive immunity
transient, IgG mediated immunity, no memory cells are produced, such as in mother’s milk
IL-3 acting on a pluripotent stem cell commits it to become
lymphoid progenitor cell
IL-3 + GMCSF acting on a pluripotent stem cell commits it to become
myeloid progenitor cell
All T-cells are CD?+
CD3+
Helper T-cell designation
CD4+
Cytotoxic T-cell designation
CD8+
