Intro to Immunology-Diebel

Question 1

What type of antibody is secreted?

Answer 1

IgA (secretory IgA–sIgA)

Question 2

Which cell type is the first contact with an invading organism?

Answer 2

macrophages

Question 3

Which cell type first attacks an invading organism?

Answer 3

neutrophils

Question 4

Toll-like receptors

Answer 4

located on phagocytic antigen-presenting cells

bind to PAMPs

Question 5

PAMP

Answer 5

pathogen-associated molecular patterns

ie flagella, LPS, etc.

Question 6

Phagolysosome function

Answer 6

phagocytize bacteria, present antigens on MHC-II

Question 7

TLR3 binding molecule

Answer 7

dsRNA

Question 8

IRF3

Answer 8

transcription factor in TLR3 cascade

Question 9

NFkB

Answer 9

transcription factor in TLR3 cascade

Question 10

What is the basic molecular basis of complement?

Answer 10

enzyme cascade in serum that binds to invading organisms and facilitates phagocytosis

Question 11

What are the myeloid precursor derivatives?

Answer 11

macrophages, dendritic cells, neutrophils, mast cells

Question 12

What are the lymphoid precursor derivatives?

Answer 12

T-cell, B-cell (–>plasma cell)

Question 13

Myeloid precursors give rise to this class of cells

Answer 13

antigen presenting cells

Question 14

Opsonization

Answer 14

promotes binding of PAMPs to TLR favorable

Question 15

What type of infection does interferon help fight?

Answer 15

viral

Question 16

Where do B-cells mature?

Answer 16

marrow

Question 17

Where do T-cells mature?

Answer 17

thymus

Question 18

What is the major difference between cytokine and hormone release?

Answer 18

cytokines are produced only in response to infection and are not generally stored

Question 19

Chemokines vs cytokines

Answer 19

chemokines are subtype of cytokines that attract cells into inflamed tissues and play a role in leukocyte homing

Question 20

Chemokines vs cytokines

Answer 20

chemokines are subtype of cytokines that attract cells into inflamed tissues and play a role in leukocyte homing

Question 21

Type 1 interferons are produced by

Answer 21

viral infected cells

Question 22

Type 2 interferons are produced by

Answer 22

activated T-H1 cells through antigen

Question 23

T/F B-cells need to be present at site of infection to be effective

Answer 23

F

Question 24

T/F T-cells need to be present at site of infection to be effective

Answer 24

T

Question 25

How do antibodies re-link the adaptive immune system with the innate immune system?

Answer 25

antibodies are produced by B-cells
phagocytic cells of innate immune system recognize Fc region of antibodies bound to bacteria and phagocytize the organism

Question 26

Active immunity

Answer 26

acquired from infection, results in memory cell formation

Question 27

Passive immunity

Answer 27

transient, IgG mediated immunity, no memory cells are produced, such as in mother’s milk

Question 28

IL-3 acting on a pluripotent stem cell commits it to become

Answer 28

lymphoid progenitor cell

Question 29

IL-3 + GMCSF acting on a pluripotent stem cell commits it to become

Answer 29

myeloid progenitor cell

Question 30

All T-cells are CD?+

Answer 30

CD3+

Question 31

Helper T-cell designation

Answer 31

CD4+

Question 32

Cytotoxic T-cell designation

Answer 32

CD8+