Goueli Essentials

Question 1

Which drug, used to treat tuberculosis, causes a defiency in vitamin B6?

Answer 1

isoniazid

causes microcytic anemia

Question 2

Which drug, used to treat tuberculosis, causes a defiency in vitamin B6?

Answer 2

isoniazid

Question 3

What is the difference between direct and indirect billiruben?

Answer 3

direct: conjugated billiruben, high = biliary tree obstruction
indirect: non-conjugated billiruben, high = billiruben not making it to liver in time = hemolysis

Question 4

Porphyria cutaneia tarda is famous for bring which disease with it?

Answer 4

hepatitis C

Question 5

An otherwise healthy older male or post-menaposal female is found to have iron deficiency anemia–what do you suspect and what do you do?

Answer 5

occult colon cancer bleed
occult blood in stool
colonoscopy?

Question 6

How do you treat hemochromatosis?

Answer 6

phlebotomy

Question 7

An otherwise healthy older male or post-menaposal female is found to have iron deficiency anemia–what do you suspect and what do you do?

Answer 7

occult colon cancer bleed
occult blood in stool
colonoscopy?
*also suspect bladder cancer–look for occult blood in urine

Question 8

How do you treat hemochromatosis?

Answer 8

phlebotomy

Question 9

How does the HFE gene cause hemochromotosis?

Answer 9

HFE (high Fe) gene normally turns on the expression of hepcidin and hepcidin normally binds ferroportin on the basolateral surface of enterocytes, preventing excess influx of iron in high-iron situations. when this gene is damaged ferroportin cannot be stopped from pumping more iron in –> bad news bears, iron overload

Question 10

Why don’t vegetarians absorb iron as well as carnivores?

Answer 10

Fe3+ (ferric) in veggies needs to be converted to Fe2+ (ferrous) before it can be transferred into circulation