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IHO Wk 1 > Circulating Blood-Downing > Flashcards

Circulating Blood-Downing Flashcards

1
Q

Serum =

A

plasma - clotting proteins

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2
Q

Normal erythrocyte count in males and females

A

males: 5x10^6/mm3
females: 4.5x10^6/mm3

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3
Q

RBC diameter

A

7.7 µm

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4
Q

RBC energy

A

anaerobic glycolysis and pentose phosphate pathway

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5
Q

Roulous

A

stacked RBCs on slides

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6
Q

Lifespan of RBCs

A

120-130 days

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7
Q

Lifespan of platelets

A

8-10 days

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8
Q

Normal platelet count

A

400,000/mm3

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9
Q

Megakaryocytes are found

A

in bone marrow

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10
Q

Two areas of platelets

A

granulomere (central)

hyalomere (peripheral)

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11
Q

Lamba granules of platelets contain

A

lysosomes

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12
Q

Diapedesis occurs most commonly in this area

A

post-capillary venule

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13
Q

Granulocytes

A

neutrophils
basophils
eosinophils

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14
Q

Agranulocytes

A

monocytes

lymphocytes

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15
Q

Neutrophil amount in differential

A

50-70%

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16
Q

Nuclei of neutrophils

A

muli-lobed

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17
Q

Azurophilic granules in neutrophils

A

primary: 20%
reddish purple
contain myeloperoxidases

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18
Q

Neutrophilic granules

A

specific: 80%

Hydrolases active at neutral or alkaline pH

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19
Q

2 killing mechanisms of neutrophils

A
  • enzymatic

- reactive oxygen species production

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20
Q

Neutrophilic granule function

A

bacteriocidal

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21
Q

Azurophilic granule function

A

bacterial digestion

22
Q

What enzyme produces reactive oxygen species in lysosomes?

A

NADPH oxidase

23
Q

Eosinophil differential count

A

1%

24
Q

Eosinophil nucleus

A

bilobular

25
Q

Which amino acid is high in eosinophils?

A

arginine

26
Q

Eosinophils contain these two crystalline substructures

A

major basic protein

eosin

27
Q

Eosinophils contain these to crystalline substructures

A

major basic protein

eosinophilic cationic protein

28
Q

What to eosinophils fight?

A
  • allergies
  • inflammatory reactions
  • parasitic worm invasions
29
Q

Basophil differential

A

0.5%

30
Q

Basophil nucleus

A

difficult to see

31
Q

Basophil function

A

initiate allergic and inflammatory responses–similar to mast cells

32
Q

Basophil function

A

initiate allergic and inflammatory responses–similar to mast cells

33
Q

Basophils have Fc receptors for fragments of

A

IgE

34
Q

Granulocytes are mitotic/amitotic in blood

A

amitotic

35
Q

Lymphocytes are mitotic/amitotic in blood

A

mitotic

36
Q

Lymphocyte differential %

A

20-40%

37
Q

Types of lymphocytes

A

B-cells
T-cells
NK-cells

38
Q

B-cell fates

A

Plasma cells –> antibodies

Memory B-cells

39
Q

B-cell lymphocyte %

A

15%

40
Q

T-cell lymphocyte %

A

80-90%

41
Q

3 type of T-cells

A

CD4+ helper T-cells
CD8+ cytotoxic T-cells
supressor T-cells

42
Q

NK cell functions

A

kill virally infected and neoplastic cells

43
Q

Monocyte differential %

A

2-8%

44
Q

Monocyte nucleus

A

kidney-bean shaped, vacuoles seen in cytoplasm

45
Q

Granulocytes in lymph indication

A

underlying pathology

46
Q

Lymph coagulates quickly/slowly

A

slowly

47
Q

Is lymph highly oxygenated?

A

no

48
Q

Chylomicrons

A

fat + plasma proteins

49
Q

Hemoconia

A

plasma “junk”

50
Q

Blood cells exit BM through

A

sinusoidal capillaries

IHO Wk 1 (13 decks)

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