Hematopoietic Tissue-Downing Flashcards
What are the types of hematopoietic tissue?
myeloid and lymphatic
Where is myeloid tissue located?
medullary cavity of bones
Where is lymphatic tissue located?
lymph organs: thymus, lymph nodes, spleen, non-encapsulated lymph organs
What tissue type is hematopoietic tissue derived from?
mesenchyme (except thymus)
From which embryonic structure is hematopoietic tissue derived from?
yolk sac
Colony forming units
from yolk sac
form hematopoietic outposts in liver, spleen, and bone
Major site of blood formation during fetal life
liver
Which bone is first to develop a medullary cavity for myeloid tissue?
clavicle
Extramedullary myelopoiesis
pathological
Two types of bone marrow
yellow: mostly fat, can be converted
red: site of hematopoiesis
Two components of myeloid tissue
parenchyma: fibroblasts, macrophages, fat-storing cells, osteogenic cells
stroma: collagenous fibers, reticular fibers (type III collagen)
What type of capillaries permit red and white cells to enter circulation
sinusoidal
How many RBCs are produced per second?
1.5 million
How long do RBCs need to mature
1 wk
Bast cells (RBC) nuclei
multiple nucleoli on progenitor cells, negatively stained
Myeloblast and erythroblast common features
large nuclei with nucleoli
rims of basophilic cytoplasm
Granulocyte order of differentiation
CFU Myeloblast Pro-myelocyte Myelocyte (differentiated) Metamyelocyte (amitotic) Band cell Mature cell
Both T- and B-cells populate __________ after they are formed in the thymus and bone marrow, respectively
secondary lymphoid organs