intro to diabetes Flashcards
what is diabetes?
a chronic multi-system disease related to abnormal or impaired insulin utilization
how is diabetes characterized?
by hyperglycemia resulting from lack of insulin, lack of insulin effect, or both
what is the cause of diabetes?
normally a combination of genetics, autoimmune, and lifestyle; absent or insufficient and/or poor utilization of insulin
what can diabetes occur from?
medical treatments like removing some or all of pancreas, corticosteroids (high dose can cause type 2), thiazides, certain antipsychotics, etc cause diabetes type 2
what are the two functions of the pancreas?
exocrine function and endocrine function
what is the exocrine function of the pancreas and what percentage of the total function is it?
it produces enzymes for digestion; 95%
what is the endocrine function of the pancreas and what percentage of the total function is it?
islet of langerhans (regulate blood sugar and pancreatic secretions), secrete insulin and glucagon; 5%
what does the liver do?
it stores and produces glucose
insulin does what?
lowers blood sugar
glucagon does what?
raises the blood sugar
what is insulin made by in the pancreas?
beta-cells
what is glucagon made by in the pancreas?
alpha-cells
where is glucose stored?
in the liver and muscle cells as glycogen
which tissues in the body are insulin dependent?
skeletal muscle and adipose tissue
insulin is required to “unlock” receptor sites in cells which allows what?
transport of glucose into cells to be used for energy
what are the three counterregulatory hormones?
epinephrine, growth hormone, cortisol, and glucagon
what do counterregulatory hormones do?
help to stimulate a high glucose level if the body is in destress (decrease glucose movement into the cell)
epinephrine does what?
comes from the liver, and promotes sugar production
how/when is insulin normally released?
released in small increments when food is ingested, it’s a storage hormone
how much insulin is normally produced in a day?
40-50 units per day, 0.6 kg/day
what tissues need glucose to function properly?
brain, liver, etc
what is insulin resistance?
pathological condition in which cells either fail to respond normally to the hormone insulin or downregulate receptors in response to hyperinsulinenemia
what glucose level is considered hypoglycemia?
< 70 mg/dl
what is insulin insufficiency?
the body makes some insulin but more insulin is needed to effectively lower the blood sugar
is hyperglycemia or hypoglycemia more dangerous?
hypoglycemia
what causes hypoglycemia?
it occurs when there is too much insulin in proportion to available glucose
what happens in the body during a hypoglycemic event?
counterregulatory hormones are released; suppression of insulin secretion & production of glucagon and epinephrine provide a defense against hypoglycemia
how quickly do symptoms of hypoglycemia happen?
onset is rapid and needs to be treated ASAP
what can untreated hypoglycemia cause?
can progress to loss of consciousness, seizures, coma, and death (can mimic alcohol intoxication)
what are causes of hypoglycemia?
alcohol intake without food, too little food, too much diabetic medication (insulin, orals), too much exercise without adequate food intake, weight loss without change in medications, sedentary lifestyle with an unusually active day
what are 12 signs and symptoms of hypoglycemia?
cold, clammy skin (give candy); numbness of of fingers, toes, mouth; tachycardia, palpitations; headache; nervousness, tremors; faintness, dizziness; stupor; slurred speech; hunger; changes in vision; seizures, coma; irritability
do changes in vision from hypoglycemia damage your eyes?
no, the changes in vision are caused by how it affects the brain and how the brain processes the info received
what are physiological consequences of hypoglycemia?
neurological symptoms and hypoglycemia unawareness
what is hypoglycemia unawareness?
it is normally found in older people; they don’t know when their sugar is low until it is extremely low. Can be caused by beta blockers or hypoglycemia happens often
_____ hormones are released, and the ____ ____ is activated
counterregulatory hormones; autonomic system
epinephrine release causes manifestations of:
shakiness, palpitations, nervousness, diaphoresis, anxiety, hunger, and pallor
the ___ needs a constant supply of glucose in sufficient quantities to function properly, hypoglycemia can affect ____ functioning
brain; mental functioning
hypoglycemia can mimic ____ ____
alcohol intoxication
what are treatments for hypoglycemia?
rule of 15, IV dextrose, Glucagon IM or sub-q, and Baqsimi (glycagon) nasal
what is the rule of 15?
have 15 grams of carbohydrate (simple sugar) to raise your blood glucose and check after 15 minutes; can repeat 2-3 times if needed and if it doesn’t help contact the provider
what is Baqsimi (glycagon) nasal?
a nasal spray that can be used when a patient is unconscious because mucous membranes will absorb the medication
what is a common side effect of glucagon and baqsimi?
nausea, so turn pt on their side and when they wake up give them carbs to eat
what are the factors affecting hypoglycemia during hospitalization?
overuse of SSIs, lack of dosage changes when dietary intake is changed, overly vigorous treatment of hyperglycemia, delayed meal after fast-acting insulin is used
what glucose level is considered hyperglycemia?
> 200 mg/dl
when does hyperglycemia occur?
when there is not enough insulin working and/or too much glucose in the blood
how quickly do symptoms of hyperglycemia happen?
they have more a gradual onset than hypoglycemia
what can untreated hyperglycemia lead to?
diabetic ketoacidosis (DKA) or hypersmolar hyperglycemia syndrome (HHS), coma and death
what are 7 causes of hyperglycemia?
illness/infection, corticosteroids, too much food, not enough diabetic medication (insulin, oral), inactivity, emotional/physical stress, and poor absorption of insulin
what are 12 s/s of hyperglycemia?
hot & dry (sugar is high); increased urination (polyuria), increased thirst (polydipsia), increased hunger (polyphagia); weakness, fatigue; blurred vision; headache; glycosuria (presence of glucose in urine); nausea, vomiting, abdominal cramps; progression to DKA, HHS; mood swings, slow healing wounds/infections
do changes in vision from hyperglycemia damage your eyes?
yes it damages the structures in your eyes
what are treatments for hyperglycemia?
continued diabetic medications, check blood glucose frequently, check urine for ketones, drinks fluids at least on an hourly basis, exercise or stay active, notify HCP if blood glucose levels do not decrease in a few days
factors affecting hyperglycemia:
hospitalization, changes in treatment regimen, medications, IV dextrose, overly vigorous treatment of hypoglycemia
what are factors affecting hyperglycemia during hospitalization?
changes in treatment regime, medications, IV dextrose, and overly rigorous treatment of hypoglycemia
what are four diagnostic studies for diabetes?
HA1C, fasting plasma glucose (FPG), oral glucose tolerance test, and random blood glucose
what is the Hemoglobin A1C (HA1C) test?
reflects the average blood glucose levels over the past 2-3 months by looking at glycosylated hemoglobin
what is glycosylated hemoglobin?
hemoglobin that is glucose bound
what is the normal range of an H1AC?
less than 5.7%
what is the pre-diabetic range of an H1AC?
5.7%- 6.5%
what is the diabetic range of an H1AC?
6.5% and higher
what can cause an H1AC count to be incorrect?
blood loss, blood transfusions, pregnancy, different diseases that affect RBCs, etc
what is a fasting plasma glucose (FBG) test?
checks fasting blood sugar levels, blood is drawn 8 hours after the last meal eaten
what is a normal range for FBG?
less than 100 mg/dl
what is the pre-diabetes range for FBG?
100-125 mg/dl
what is the range for diabetic range for FBG?
126 mg/dl or higher
what is the oral glucose tolerance test (OGTT)?
two hour test that checks blood sugar before and two hours after a glucose; shows how well your body processes sugar
what is the normal range for OGTT?
less than 140 mg/dl
what is the pre-diabetic range for OGTT?
140-199 mg/dl
what is the diabetic range for OGTT?
200 mg/dl
what is the random blood glucose test?
can be drawn at any time, seen on a BMP or CMP