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Pharma B > Intro To CNS > Flashcards

Intro To CNS Flashcards

1
Q

Determinants for entry

A 
Molecular weight
Lipophilicity
Charge
Polarity
Small unionized, uncharged and non polar
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2
Q

Factors that can increase access to the brain

A

Cerebal ischemia

Inflammation

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3
Q

Toxins for sodium channels

A

Tetradotoxin - puffer fish

Batrachotoxin - colombian frog

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4
Q

Toxins potassium

A

Apamin - small - honeybee

Charybdotoxin - big - scorpion

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5
Q

Neurohormonea

A

Oxytocin

Arginine Vasopressin

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6
Q

Neuromodulators

A 
CO2
Adenosine
Purines
Eicosanoids
NO
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7
Q

NMDA mechanism

A

Calcium Conductance

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8
Q

AMPA conductance

A

Na and K

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9
Q

Another agonist for nmda

A

Cycloserine

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10
Q

What can block nmda

A 
Dizoclipine
Phecyclidine
Ketamine
Remacemide
Memantine
MG
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11
Q

Glutamate receptor has a pre and post limited distribution

A

Kainate

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Pharma B (8 decks)

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