Antiparkinsonism And Other Movement Disorders

Question 1

Known as paralysis agitans
Shaking palsy
Resting tremors

Answer 1

Parkinsonism

Question 2

Positive symptoms of parkinsonism

Answer 2

Tremors
Athetosis
Ballismus
Chorea

Question 3

Negative symptoms of parkinsonism

Answer 3

Bradykinesia
Akinesia
Loss of postural reflexes

Question 4

Main pathologic cause of parkinsonism

Answer 4

Dopaminergic nigrostriatal pathway

Question 5

Replaces dopamine

Answer 5

Levodopa

Question 6

Peripherally acting decarboxylase inhibitors

Answer 6

Carbidopa

Benzeraside

Question 7

Dopamine agonist

Ergot derivative

Answer 7

Bromocriptine
Pergolide
Lesuride

Question 8

Dopamine agonist

Non ergot

Answer 8

Pramipexole
Ropinirole
Rotigotine

Question 9

Mao-B inhibitors

Answer 9

Selegiline

Rasagiline

Question 10

COMT inhibitors

Answer 10

Tolcapone

Entacapone

Question 11

What are the main metabolites of levodopa

Answer 11

HVA

DOPAC

Question 12

Drug interaction of Levodopa

Answer 12

B6 pyridoxine

MAO A inhibitors

Question 13

CI of Levodopa

Answer 13

Psychoses
Angle closure glaucoma
Cardiac dysrhythmia
PUD
Melanoma

Question 14

First line for parkinsonism

Answer 14

Dopamine agonist

Question 15

Dopamine D2 receptor

Answer 15

Bromocriptine

Question 16

Stimulates D1 and D2 receptor

Answer 16

Pergolide

Question 17

Potent dopamine agonist

Temporary relief

Answer 17

Apomorphine

Apokyn

Question 18

What is given before administering apomorphine

Answer 18

Trimethonenzamide

Question 19

Given to prevent mptp induced parkinsonisn

Answer 19

Rasagline

Question 20

CI of MAO B inhibitors

Answer 20

Analgesics

Question 21

Comt that has central and peripheral metabolism

Answer 21

Tolcapone

Question 22

Antiviral agent used for parkinsonism

Answer 22

Amantadine