Anti Microbials 2 Flashcards
Antibacterial activity of sulfonamides
Bacteriostatic
Poor against anaerobes
Pseduomonas resistant
Increase growth of rickettsia
What competes with paba
Dihydropteroate synthase
Short half life of sulfonamides
Sulfacystine
Sulfamethizole
Sulfaoxazole
Longest half life of sulfanomide
Sulfadoxine
Metabolism of sulfanomide
Liver via acetlylation and glucorination
Oral absorbable agent for UTI ane RTI
Sulfisoxazole and sulfamethoxazole
Given for toxoplamosis
Sulfadiazine with pyrimethamine
Associated with the use of 5ASA and ulcerative collitis
Sulfasalazine
The treatment for bacterial conjunctivitis and adjunctivr therapy for trachoma
Sodium sulfacetamide
AE hemolytic reaction with sulfonamides
Seen with G6PD
Tmp and smz are seen more in what body fluid
Prostatic and vaginal
This is used for acute UTI
Oral trimetophrim
Useful only in the treatment of lower UTI
First generation fluoroquinolones
Relaxation of positively supercoiler dna
Topoisomerase 2
Most active against gram negative especially pseudomonas aeruginosa
Ciprofloxacin
Given for ciprofloxacin resistant pneumonia
Gemifloxacin
What is initially given for CAP
Levofloxacin
What can cause impaired absorption of fluroquinolones
Antacids
Fluoroquinolones causes photosensitivity
Lomefloxacin
Perfloxacin
Contraindicated for pregnant women is.caused by
Arthropathy
QT prolongation
Levofloxacin
Moxifloxacin
Gatifloxacin
Gemifolxacin
This is potent against anaerobes, bacteriodes and clostridium
Metronidazole
Clinical uses of brain abscess
Metronidazole
Has an AE of disulfiram like effect
Metronidazole
