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Pharma B > Antiseizure > Flashcards

Antiseizure Flashcards

1
Q

Repetitive movements
Paresthesias
Flashes of light
Ipsilateral cortical region

A

Simple partial

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2
Q

Affects the amygdala and hippocampus

Preceded by aura

A

Complex partial

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3
Q

Loss of consciouness

A

Partial seizures with secondary generalization

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4
Q

Sudden, short interruptions of consciousness, blank stares, lip smacking, rapid blinks and no aura

A

Petit mal

Absence

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5
Q

Brief muscle contractions

Associated with uremia or hepatic failure

A

Myoclonic seizures

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6
Q

Abrupt onset of muscle group
Loss of consciouness
Postictal disorientation

A

Grand mal

Generalized tonic clonic

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7
Q

These drugs are good for absence type

A

Ethosuximide and Valproate

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8
Q

For generalized tonic clonic and complex partial seizure

A

Phenytoin
Carbamazepine
Lamotrigine

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9
Q

These drugs bind to plasma proteins

A

Phenytoin
Tiagabine
Valproate

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10
Q

What specifically does phenytoin target

A

Inactivated state of Na channels

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11
Q

What are the therapeutic levels of phenytoin

A

10-20

300 starting

25-30 increments

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12
Q

What may increase phenytoin

A

OCP, quinidine, doxycycline, cyclosporine, methadone and levodopa

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13
Q

Long term use of phenytoin may lead to

A

Gingival hyperplasia, hirsutism, peripheral neuropathy

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14
Q

DoC of simple and complex partial grand mal

A

Carbamazepine

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15
Q

Non sedating
Used for trigeminal neuralgia
Bipolar for manic phase

A

Carbamazepine

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16
Q

What can increase the biotransformation of carbamazepine

A 
Phenytoin
Primidone
Ethosuximide
Valproic acid
Clonazepam
17
Q

What drug can increase blood levels of carbamazepine

A

Valproic acid

18
Q

Most common side effects of carbamazepine

A

Diplopia
Ataxia
Blood dyscracias
Erythematous rash

19
Q

Given for lennox gastuat syndrome

A

Lamotrigine

20
Q

What drug can displace phenytoin

A

Valproic acid

21
Q

Given for partial seizures and analgesics

A

Gabapentin

Pregabalin

22
Q

MoA of BZD

A

Increase frequency of opening Cl channels

23
Q

This drug will worsen absence type of seizure

A

Phenobarbital

24
Q

Binds to SV2A

A

Levetiracetem

25
Q

Given for juvenile myoclonic epilepsy

A

Levetiracetem

26
Q

Inhibits GAT1

A

Tiagabine

27
Q

What are the SE of tiagabine

A 
Nervousness
Dizziness
Difficulty in concentration
Tremors
Depression
28
Q

Monosaccarhide agent user for partial and grand mal

A

Topiramate

29
Q

When do you stop topiramate

A

Myopia

Glaucoma

30
Q

DoC of infantile spasms

A

Vigabatrin

31
Q

DoC for juvenile myoclonic epilepsy

A

Valproic acid

32
Q

Dose of immediate resusitation

A

20-30mg

Pharma B (8 decks)

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