Antiseizure

Question 1

Repetitive movements
Paresthesias
Flashes of light
Ipsilateral cortical region

Answer 1

Simple partial

Question 2

Affects the amygdala and hippocampus

Preceded by aura

Answer 2

Complex partial

Question 3

Loss of consciouness

Answer 3

Partial seizures with secondary generalization

Question 4

Sudden, short interruptions of consciousness, blank stares, lip smacking, rapid blinks and no aura

Answer 4

Petit mal

Absence

Question 5

Brief muscle contractions

Associated with uremia or hepatic failure

Answer 5

Myoclonic seizures

Question 6

Abrupt onset of muscle group
Loss of consciouness
Postictal disorientation

Answer 6

Grand mal

Generalized tonic clonic

Question 7

These drugs are good for absence type

Answer 7

Ethosuximide and Valproate

Question 8

For generalized tonic clonic and complex partial seizure

Answer 8

Phenytoin
Carbamazepine
Lamotrigine

Question 9

These drugs bind to plasma proteins

Answer 9

Phenytoin
Tiagabine
Valproate

Question 10

What specifically does phenytoin target

Answer 10

Inactivated state of Na channels

Question 11

What are the therapeutic levels of phenytoin

Answer 11

10-20

300 starting

25-30 increments

Question 12

What may increase phenytoin

Answer 12

OCP, quinidine, doxycycline, cyclosporine, methadone and levodopa

Question 13

Long term use of phenytoin may lead to

Answer 13

Gingival hyperplasia, hirsutism, peripheral neuropathy

Question 14

DoC of simple and complex partial grand mal

Answer 14

Carbamazepine

Question 15

Non sedating
Used for trigeminal neuralgia
Bipolar for manic phase

Answer 15

Carbamazepine

Question 16

What can increase the biotransformation of carbamazepine

Answer 16

Phenytoin
Primidone
Ethosuximide
Valproic acid
Clonazepam

Question 17

What drug can increase blood levels of carbamazepine

Answer 17

Valproic acid

Question 18

Most common side effects of carbamazepine

Answer 18

Diplopia
Ataxia
Blood dyscracias
Erythematous rash

Question 19

Given for lennox gastuat syndrome

Answer 19

Lamotrigine

Question 20

What drug can displace phenytoin

Answer 20

Valproic acid

Question 21

Given for partial seizures and analgesics

Answer 21

Gabapentin

Pregabalin

Question 22

MoA of BZD

Answer 22

Increase frequency of opening Cl channels

Question 23

This drug will worsen absence type of seizure

Answer 23

Phenobarbital

Question 24

Binds to SV2A

Answer 24

Levetiracetem

Question 25

Given for juvenile myoclonic epilepsy

Answer 25

Levetiracetem

Question 26

Inhibits GAT1

Answer 26

Tiagabine

Question 27

What are the SE of tiagabine

Answer 27

``` Nervousness Dizziness Difficulty in concentration Tremors Depression ```

Question 28

Monosaccarhide agent user for partial and grand mal

Answer 28

Topiramate

Question 29

When do you stop topiramate

Answer 29

Myopia | Glaucoma

Question 30

DoC of infantile spasms

Answer 30

Vigabatrin

Question 31

DoC for juvenile myoclonic epilepsy

Answer 31

Valproic acid

Question 32

Dose of immediate resusitation

Answer 32

20-30mg