intro to carbs Flashcards

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1
Q

What is the most abundant molecule in nature?

A

carbohydrates

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2
Q

function of carbs in humans

A
  • significant fraction of dietary calories
  • major energy source
  • storage form of energy (glycogen)
  • cell membrane components that mediate some forms of intercellular communication and retain water
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3
Q

structural component of many organisms

A
  • cell walls of bacteria
  • exoskeleton of insects (chitin)
  • fibrous cellulose of plant cell wall (indigestible)
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4
Q

stoichiometric formula

A

(CH2O)n

consists of carbon and water in ratio of C:H:O= 1:2:1

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5
Q

monosaccharides

A
  • 1 unit
  • simple sugars
  • glucose and fructose
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6
Q

disaccharides

A

-2 monosaccharide units

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7
Q

oligosaccharides

A

3-10 monosaccharide units

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8
Q

polysaccharides

A

more than 10 monosaccharide units

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9
Q

monosaccharide classification

A
  1. according to the number of carbons they contain

2. according to the type of there most oxidized functional group

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10
Q

isomers

A

compounds that have the same chemical formula but different structures

gluctose, fructose, mannose, and galactose are all structural isomers

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11
Q

epimers

A

compounds that differ in the configuration around only one specific carbon atom

glucose and galactose are C-4 epimers
glucose and mannose are C-2

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12
Q

enantiomers

A

pairs of structures that are mirror image to each other

D-glucose and L-glucose

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13
Q

D-glucose

A

found in nature

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14
Q

L-glucose

A

cannot be metabolized

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15
Q

monosaccharides: cyclization

A

> 99% of monosaccharides with 5 or more carbons exist as a ring, in which the aldehyde or kept group has reacted with an alcohol group of the same sugar

creates an anemic carbon (isomer) that can exist in either alpha or beta form

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16
Q

pyranose

A

6 membered ring with 5 carbons and one oxygen

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17
Q

Furanose

A

5 membered ring with 4 carbons and one oxygen

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18
Q

enzyme specificity of anomeric monosaccharides

A

they are specific to one of the anemic forms

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19
Q

Glycosidic bonds

A

bonds that link sugars

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20
Q

Beta gycosidic

A

beta(1-4)

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21
Q

alpha glycosidic

A

alpha(1-4)

alpha (1-6)

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22
Q

lactose

A

glucose + galactose

Beta (1-4)

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23
Q

Sucrose

A

glucose + fructose

alpha (1-2)

24
Q

Maltose

A

glucose + glucose

alpha (1-4)

25
Q

When can the ring on a cyclic mono-disaccharide open?

A

if the OH group on the anemic carbon of a cyclized sugar is NOT linked to another compound by a glycosidic bond

26
Q

reducing agent

A

the sugar can act as a reducing agent once the ring opens

27
Q

What can be a reducing sugar?

A

all monosaccharides but not all disaccharides

28
Q

positive urine test for reducing sugars

A

indicative of underlying pathology

29
Q

glycogen

A

highly branched polymer of glucose, alpha 1-4 and alpha 1-6 linkages
major energy storage in animal (liver and muscle cells)

30
Q

amylose

A

polymer of glucose in plants

unbranched; alpha 1-4 glycosidic linkages

31
Q

Amylopectin

A

polymer of glucose in plants
branched; alpha 1-4 and alpha 1-6 glycosidic linkages
a little less branched than glycogen

32
Q

cellulose

A

unbranched glucose polymer in plants
beta 1-4 glycosidic linkages
humans can’t digest

33
Q

complex carbs

A

carbs attached to non-carb structures such as

  • purines and pyramidines
  • aromatic rings (steroids)
  • proteins (glycoproteins)
  • lipids (glycolipids)
34
Q

types of bonds by which a sugar may be attached to a non-carb group

A
  • NH2 group = N-glycosidic link (N-linked)

- OH group = O-glycosidic link (O-linked)

35
Q

Where do carbs get digested?

A
  • mouth
  • intestinal lumen
  • mucosal lining of the upper jejunum
36
Q

What digestive enzymes break down carbs?

A

glycoside hydrolases (glycosidases), use a molecule of water

37
Q

Mouth enzymes

A

salivary alpha-amylase

38
Q

intestinal lumen enzymes

A

pancreatic alpha-amylase

39
Q

enzyme of the mucosal lining of the upper jejunum

A

isomaltase, galactosidase, trehalase

40
Q

what two enzymes act the same but are secreted from different tissues?

A

salivary alpha-amylase and pancreatic alpha-amylase

41
Q

role of salivary alpha amylase

A

breaks large insoluble carbs into smaller soluble ones

42
Q

specificity of salivary alpha amylase

A

hydrolysis of alpha 1-4 bonds ONLY

43
Q

substrates of salivary alpha amylase

A

any carb with alpha 1-4 bonds (starch, glycogen, maltose)

44
Q

salivary alpha amylase products

A

short branched and unbranched oligosaccharides (dextrins)

45
Q

salivary alpha amylase pH optimum

A
  1. 0

- inactivated by the acidic pH in stomach within 20 minutes

46
Q

pancreatic alpha amylase role

A

continues to break down carb molecules into smaller soluble ones

47
Q

pancreatic alpha amylase specificity

A

hydrolysis of alpha 1-4 bonds ONLY

48
Q

pancreatic alpha amylase substrates

A

any carb with alpha 1-4 bonds (starch, glycogen, maltose, and smaller dextrin)

49
Q

pancreatic alpha amylase product

A

shorter branched and unbranched oligosaccharides (dextrin) and disaccharides

50
Q

pancreatic alpha amylase pH optimum

A

7.0

51
Q

pancreatic alpha amylase and pathology

A

plasma levels of either pancreatic amylase or total amylase are used as a diagnostic marker for pancreatitis, should not be found in plasma

52
Q

final digestions in the mucosal cells

A

all enzymes are transmembrane proteins of the brush border on luminal surface of the intestinal mucosal cells

53
Q

sucrase/isomaltase (SI)

A

1 protein-2 subunits with enzymatic activities

  • cleaves alpha 1-2 bonds in sucrose
  • alpha 1-6 bonds (branches) in isolates
54
Q

maltase-glucoamylase (MGA)

A

1 protein-2 enzymatic activities

  • cleaves alpha 1-4 bonds in maltose/maltotriose (maltase activity)
  • alpha 1-4 bonds in dextrins (glucoamylase)
55
Q

lactase

A

beta 1-4 bonds in lactose (milk sugar)

high expression in infants and gradual decrease with age

56
Q

trehalase

A

alpha 1-1 bonds in therapies (mushrooms and fungi)

57
Q

What kind of sugars get absorbed?

A

ONLY MONOSACCHARIDES. in the upper jejunum and duodenum