Intro To Anaemia Flashcards
Anaemia can be described as a
1)decrease in ____________
2) decrease in ___________
3)decrease in ____________
4)decrease in ____________
5)decrease in ____________
Red cell mass
Oxygen carrying capacity of the blood
Hb conc of the blood
Pcv of the blood
Red cell count of that blood
In adult male, oxygen delivery is impaired when Hb conc is less than _________
In adult female , oxygen delivery is impaired when Hb conc is less than _________
13g/dl
12g/dl
In children between 6-14 of both sexes, oxygen delivery is impaired when Hb conc is less than _________
12g/dl
In children between 30days- 6yrs of both sexes, oxygen delivery is impaired when Hb conc is less than _________
11g/dl
In children between 0-30days of both sexes, oxygen delivery is impaired when Hb conc is less than _________
13.5g/dl
1g of Hb would bind to ____ml of oxygen
1.34
Hb conc of 15g/dl would contain ____ml of oxygen
Meaning that,
For every ____ml of blood, there is __g of Hb
Which means that for every ____ of blood, ___ml of oxygen
20-1
100;15
100;20.1
___ml = 1dl
100
Hb conc of 10g/dl would contain ____ml of oxygen
13.4
Oxygen tension of blood is the __________
Amount of oxygen present in 100ml of blood
Normal oxygen tension of blood is _______
20 volume %
With decrease in Hb conc of blood, oxygen tension of blood __________
reduces
When oxygen tension of blood is 20volume% , the partial pressure of oxygen in the blood is ____mmHg
100
When the oxygen tension of blood is 15volume%, the partial pressure of the blood is only ____mmHg
40
Arterial blood has oxygen tension of _____ and partially pressure of ——-
Venous blood has oxygen tension of _____ and partially pressure of ——-
20; 100
15; 40
In terms of oxygen tension, the arteriovenous difference sub??
5volume%
4 Physiological adaptations of Anaemia
1)modulation of ______
2)_______ mechanism/______ mechanism
3)________ of blood flow from___ to ____
4)Mechanism to widen the narrowed ________ by bringing down the ____
Hb’s Oxygen affinity
Cardiovascular adaptive/compensatory
Redistribution;less o2 sensitive organs to more o2 sensitive organs
Arteriovenous oxygen difference ; venous oxygen blood tension
Modulation of Hb’s oxygen binding affinity
By oxygen affinity Hb, we mean the ____/_____ with which Hb binds/complexes with oxygen
Avidity
Tenacity
The normal haemoglobin is created in such a way that under ___ partial pressure of oxygen , it avidly combines with oxygen and under ____ partial pressure of oxygen, it readily parts with oxygen
high
low
High oxygen affinity haemoglobin
They bind with oxygen at _________ partial pressure and ____________
High and low
Do not part with oxygen
Low oxygen affinity haemoglobin bind with oxygen at _________ partial pressure of oxygen
Only very high
Low oxygen affinity haemoglobin readily picks up oxygen from the lungs
T/F
F
In anaemic conditions , the love of oxygen by normal haemoglobin is (increased or decreased?)
Decreased
Reduction of oxygen’s affinity by normal Hb is pathological
T/F
F
Physiological
In glycolytic/ _________ pathway, G3P is broken down to _____ which is broken down to _____ so as to generate ____ but ____ is not interested in doing that
Embden-Meyerhoff
1,3PG
3PG
Anaemic Rbc
Anemic rbc converts 1,3 DPG to ______ using _____ enzyme
2,3 DPG
1,3 DPG mutase
A proton is usually emitted when _____________ happens
Hb complexes with oxygen
HHb + o2 ——> ______ + ____
Hbo2-
H
Hbo2- is known as _______
Oxyhemoglobin
Oxyhemoglobin is found in the acidic or alkaline milleiu?
Acidic
The mechanism by which 1,3 DPG is converted to 2,3 DPG is called ____________ pathway or _________ shunt
Energy clutch
Rapoport lubering
Rapoport lubering shunt generates ATP
T/F
F
In Anaemic rbcs, Hb exists as ???
HHb or Hbo2-
HHb
________ stimulates 1,3 DPG mutase
Alkalinity of the cytoplasm of the anaemic rbc
2,3 DPG is that molecule that is capable of complexing with ____ and allow ____ to be ________at ______ partial pressure of oxygen and permits oxygen to be ____
Hb
O2
Detached from Hb
Low
Moved into the tissue
We say that ______________ is the most important adaptive mechanism to anemia
Generation of 2,3 DPG
The hypoxia of blood vessels results in ___________
Vascular dilatation
Hypoxia of blood vessels leads to ____eased peripheral resistance
Decr
The HR changes in anemia to as high as ___ or ____ bpm or more
90
100
In Anaemia, CO is affected
T/F
T
Cardiac output = ___ x ___
SV
HR
Normal
CO?
SV?
HR?
5L
70ml
72bpm
What is the oxygen carrying capacity of the normal CO of the body?
1000ml
Out of the 1000ml of oxygen that reaches the body at each pump,the body only requires about ____ml of oxygen per minute
250
Out of the essential 250ml of oxygen that the body needs per minute, the brain alone consumes about __ml of it, the heart consumes about __ml of it, while the muscle mass consumes about __ml of it
60
50
60
The oxygen sensitive tissues of the body includes the ____,_____, and ____
Heart
Brain
Skeletal muscle
Cardiovascular adaptive mechanism is equally vital as a survival mechanism as much as the modulation of Hb’s oxygen affinity
T/F
T
The cardiovascular adaptive mechanism has no energy implications
T/F
F
It does
The cardiovascular adaptive mechanism will easily fail if the Hb conc falls to the extreme
T/F
T
The failure of ______ is usually the cause of death in severe anaemic conditions
The cardiovascular adaptive mechanism
The cardiovascular adaptive mechanism is effective when the Hb conc is between ______ g/dl
7 and 8
With the Hb conc of ______ , the cardiovascular adaptive mechanism will fail
Less than 7g/dl
We define severe Anaemia in adults as Hb conc being ______because at this level , _________ would appear and at __________ the whole thing would fail
Less than 8g/dl
Features of failure of cardiovascular adaptive mechanism
7g/dl
In children less than ____ years, The cardiovascular adaptive mechanism may not fail until the Hb conc level is ____ or below
5
5g/dl
The feature of The cardiovascular adaptive mechanism is :
- Very high ________
- ______ failure
- _______ failure
Heart rate
Right ventricular heart
Left ventricular heart
Right ventricular heart failure usually manifests as:
- Raised ———-
2.________/________
3._______ - _____ dependent ______
Jugular venous pressure
Hepatomegaly/hepatoplenomegaly
Ascites
Gravity; leg edema
Ascites = excess ________
Abdominal fluid