Intro/Antibody Function L2

Question 1

What is Multiple Myeloma?

Answer 1

• Plasma Cell Tumor

- Disrupte normal hematopoiesis

Question 2

What does Myeloma do?

Answer 2

• Decrease WBC

- More prone to infections

Question 3

List the Immunoglobulin Classes

Answer 3

• IgM
• IgD
• IgG
• IgA
• IgE

Question 4

How many total isozymes (immunoglobulin classes) are there?

Answer 4

9

Question 5

Which antibody(-ies) does Ag specific receptor best?

Answer 5

All isotypes

Question 6

Which antibody(-ies) does neutralization best?

Answer 6

IgG and IgA

Question 7

Which antibody(-ies) does complement activation best?

Answer 7

IgM and IgG

Question 8

Which antibody(-ies) does oponization best?

Answer 8

IgG

Question 9

Which antibody(-ies) does ADCC best?

Answer 9

IgG

Question 10

Which antibody(-ies) does Mast Cell activation best?

Answer 10

IgE

Question 11

Which processes are FcR dependent?

Answer 11

ADCC
Mast Cell Activation
Oponization

Question 12

Define Epitope

Answer 12

The part that the antibody recognizes

Question 13

Which two Ig classes can for polymeric immunoglobulins?

Answer 13

IgM and IgA

Question 14

What do the heterodimers IgAlpha and IgBeta do?

Answer 14

Send signals to the cell that it is on

Question 15

What do naive B cells contain?

Answer 15

IgM and IgD

Question 16

What do BCR memory B cells contain?

Answer 16

IgG, IgA or IgE BUT NEVER more than one of them

Question 17

What does BCR stand for?

Answer 17

B cell membrane Ig

Question 18

What type of cell does the Antibody-Dependent Cellular Cytotoxicity (ADCC) use?

Answer 18

Natural Killer cells

Question 19

What Ig’s do babies obtain

Answer 19

1. IgG

2. IgA (If breast fed)

Question 20

What is the half life of IgG?

Answer 20

3-4 WEEKS