Antigen receptor Diversity L3 Flashcards
What does the Naive B cell consist of in terms of Ig?
IgM and IgD
What does “Naive” B cell mean?
It has not been in contact with an Ag
T/F: IgM and IgD do not have ths ame specificity
FALSE
They do have the same specificty
What does the light chain consist of?
VJC (C=constant region)
What does the Heavy chain consist of?
VDJC
What does VDJ recombination require?
RAG-1 and RAG-2 proteins
Where are RAG 1 & RAG 2 expressed?
In both B and T cells
What happens of RAG 1 or RAG 2 or both are absent or defective?
NO ACQUIRED IMMUNITY
What is the Magnitude of VDJ?
V > D > J
Name the 5 Generation Ab diversity?
- Germline
- Combinational
- Junctional
- Somatic Hypermutation
T/F: high affinity is crucial for Ab system
TRUE
What is Class Switching Recombination?
Using different constant regions
T/F Class Switching Recombination is disctint from VDJ recombination
TRUE
What is Somatic Hypermutation?
Point mutations occuring in variable regions of heavy and ligh chains
Where does CSR and SHM occur?
In germinal centers of the secondary lymphoid organs
