B cell development L4 Flashcards
Where are B and T cells initially made?
Bone
Where does the T cell “grow”
Thymus
What happens in the Pre-B cell stage?
Heavy and Light chain rearrangement
Once Heavy and Light chain are rearranged, what type of B cell do you have?
Immature B cell
Where does an Immature B cell stay?
Bone
What happens if an Immature B cell sees Ag?
It will undergo apoptosis
When does the B cell leave the bone marrow?
When it is mature
T/F A mature B cell out of the bone marrow is a naive B cell
True
What are the two types of immunity?
Passive or Active
What is Passive Immunity?
-Mediated by transfer of pre-formed Ab
What are examples of Active Immunity
-Mediated by adaptive immune response to Ag
What are the sub groups of Active and Passive Immunity?
- Natural
- Artificial
What is an example of Passive Natural Immunity?
Maternal IgG present in newborn
IgA in milk
What is an example of Passive Artificial Immunity?
Injection of Ig
- RIF [rabies] - IVIG [taken from normal people/given routinely to increase]
What is an example of Active Natural Immunity?
- Infected with actual pathogen (getting sick)
